Document Detail


Marine phospholipids--a promising new dietary approach to tumor-associated weight loss.
MedLine Citation:
PMID:  19404684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
GOALS OF WORK: Advanced tumor disease very often evokes excessive loss of body weight. Among others, fish oil or marine fatty acid ethyl esters were investigated for treatment of cancer cachexia with controversial results. In this study, a new formulation of marine fatty acids was investigated, the marine phospholipids, with more than 50% of phospholipid-bound fatty acids being eicosapentaenoic and docosahexaenoic acid. MATERIALS AND METHODS: Thirty-one tumor patients with various tumor entities suffering from weight loss were asked to take marine phospholipids (1.5 g/day) as softgel capsules for a period of 6 weeks. Compliance, body weight, appetite, and quality of life as well as the fatty acid profile in plasma and blood cells were monitored; 17 patients could be analyzed. MAIN RESULTS: Marine phospholipids were very well accepted; low-dose supplementation resulted in a significant increase of eicosapentaenoic and docosahexaenoic acid in plasma phospholipids; therefore, significantly reducing the n-6 to n-3 fatty acid ratio. A stabilization of body weight was achieved (median weight change of +0.6% after 6 weeks), while appetite and quality of life improved. CONCLUSIONS: These promising first results encourage further investigation of marine phospholipids in cancer care.
Authors:
Lenka A Taylor; Lars Pletschen; Jann Arends; Clemens Unger; Ulrich Massing
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-29
Journal Detail:
Title:  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer     Volume:  18     ISSN:  1433-7339     ISO Abbreviation:  Support Care Cancer     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2009-12-18     Completed Date:  2010-02-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9302957     Medline TA:  Support Care Cancer     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  159-70     Citation Subset:  IM    
Affiliation:
Department of Clinical Research, Tumor Biology Center, Breisacher Strasse 117, 79106, Freiburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Body Weight / drug effects
Cachexia / blood,  prevention & control*
Capsules
Dietary Supplements
Fatty Acids / blood
Female
Fish Oils / administration & dosage*
Humans
Interleukin-1 / blood
Interleukin-6 / blood
Male
Middle Aged
Neoplasms / complications*
Nutritional Status
Phospholipids / administration & dosage*,  blood
Quality of Life
Weight Loss / drug effects*
Chemical
Reg. No./Substance:
0/Capsules; 0/Fatty Acids; 0/Fish Oils; 0/Interleukin-1; 0/Interleukin-6; 0/Phospholipids

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