Document Detail


Marine n-3 polyunsaturated fatty acids in adipose tissue and breast cancer risk: a case-cohort study from Denmark.
MedLine Citation:
PMID:  19711189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The aim of this study was to investigate the association between the content of marine n-3 polyunsaturated fatty acids (PUFA) in adipose tissue, a biomarker for the long-term intake of seafood, and the subsequent development of breast cancer (BC). DESIGN: We designed a case-cohort study based on a cohort of healthy Danish women, who in the 1990 s donated adipose tissue biopsies to a biobank in order to investigate the role of diet for the development of cancer and chronic disease. During follow-up, incident cases of BC were identified through national registries, and the content of n-3 PUFA in adipose tissue was compared between cases and the cohort sample. RESULTS: During follow-up, 463 new cases of BC were identified. After adjusting for potential confounders, no significant association between the content of marine n-3 PUFA and BC was found. When comparing the highest with the lowest quintile, the hazard ratio (HR) was 0.96 (95% CI 0.64-1.43) for total marine n-3 PUFA, 0.84 (95% CI 0.58-1.23) for eicosapentaenoic acid (EPA), and 1.08 (95% CI 0.73-1.58) for docosahexaenoic acid (DHA). CONCLUSION: This study does not indicate any association between the content of total or individual marine n-3 PUFA in adipose tissue and development of BC.
Authors:
Petra M Witt; Jeppe H Christensen; Erik B Schmidt; Claus Dethlefsen; Anne Tj??nneland; Kim Overvad; Marianne Ewertz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-27
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  20     ISSN:  1573-7225     ISO Abbreviation:  Cancer Causes Control     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-27     Completed Date:  2010-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1715-21     Citation Subset:  IM    
Affiliation:
Department of Oncology, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-22, 9100, Aalborg, Denmark. p.witt@rn.dk
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / chemistry*
Aged
Breast Neoplasms / chemistry*,  pathology
Case-Control Studies
Denmark
Fatty Acids, Omega-3 / analysis*
Female
Humans
Middle Aged
Neoplasm Staging
Risk Factors
Tumor Markers, Biological / analysis*
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Tumor Markers, Biological

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