Document Detail


Marine algae: screening for a potent antibacterial agent.
MedLine Citation:
PMID:  17594989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was done to investigate the antimicrobial potentiality of the marine algae collected from different coastal regions of Gujarat and screened for the same. Twenty-six marine algae belonging to Rhodophyceae, Chlorophyceae and Phaeophyceae were screened for their potential antibacterial activity against five clinically important bacterial strains, namely Bacillus cereus, Micrococcus flavus, Citrobacter freundii, Klebsiella pneumoniae and Pseudomonas testosterone. Acetone and methanol were used for extraction; and the extracted yield was more when the solvent used was methanol. The antibacterial activity was done by both Agar disc diffusion method and Agar ditch method. The five bacterial strains showed varied response towards marine algal extracts. The most susceptible bacteria was B. cereus followed by K. pneumoniae and C. freundii while the most resistant bacteria were M. flavus and P. testosteroni. Among the 26 algae screened, E. intestinalis was the most potent alga and thus, this alga was selected for further studies. E. intestinalis was extracted in petroleum ether, 1,4-dioxan, acetone, methanol and DMF, and their antibacterial activity was studied against the above-stated five bacterial strains using agar disc method. Maximum extractive value of E. intestinalis was in methanol (2.05%) and minimum was in acetone (0.38%). The most susceptible bacteria was K. pneumoniae and maximum antibacterial activity was shown by petroleum ether extract and minimum was shown by 1,4-dioxan extract. The most resistant bacteria were M. flavus and C. freundii. The MIC values of E. intestinalis extracts ranged from 2500-9.765 microg/0.5 ml against B. cereus and K. pneumoniae. From these results it is concluded that the acetone extract of E. intestinalis is the most potent extract and can be used as a lead molecule in drug discovery in inhibiting some of the bacterial strains. E. intestinalis can be used as a promising novel marine antimicrobial agent in the coming years.
Authors:
Ratish Nair; Rajesh Chabhadiya; Sumitra Chanda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of herbal pharmacotherapy     Volume:  7     ISSN:  1522-8940     ISO Abbreviation:  J Herb Pharmacother     Publication Date:  2007  
Date Detail:
Created Date:  2007-06-27     Completed Date:  2007-10-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888586     Medline TA:  J Herb Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-86     Citation Subset:  IM    
Affiliation:
Dept of Biosciences, Saurashtra University, Rajkot, Gujarat, 360 005, India.
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MeSH Terms
Descriptor/Qualifier:
Algae*
Anti-Bacterial Agents / pharmacology*
Bacillus cereus / drug effects
Citrobacter freundii / drug effects
Drug Resistance, Bacterial
Gram-Negative Bacteria / drug effects*
Gram-Positive Bacteria / drug effects*
Haemophilus influenzae / drug effects
Humans
India
Klebsiella / drug effects
Klebsiella pneumoniae / drug effects
Microbial Sensitivity Tests
Micrococcus / drug effects
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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