Document Detail


Marine food pollutants as a risk factor for hypoinsulinemia and type 2 diabetes.
MedLine Citation:
PMID:  21364465     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Some persistent environmental chemicals are suspected of causing an increased risk of type 2 diabetes mellitus, a disease particularly common after the age of 70. This concern was examined in a cross-sectional study of elderly subjects from a fishing population with elevated contaminant exposures from seafood species high in the food chain.
METHODS: Clinical examinations of 713 Faroese residents aged 70-74 years (64% of eligible population) included fasting plasma concentrations of glucose and insulin, and glycosylated hemoglobin. Lifetime exposure to persistent environmental chemicals from pilot whale and other traditional food was estimated from a dietary questionnaire and by analysis of blood samples for polychlorinated biphenyls (PCBs) and related food contaminants.
RESULTS: Septuagenarians with type 2 diabetes or impaired fasting glycemia tended to have higher PCB concentrations and higher past intake of traditional foods, especially during childhood and adolescence. In nondiabetic subjects, the fasting insulin concentration decreased by 7% (95% CI = -12% to -2%) for each doubling of the PCB concentration after adjustment for sex and body mass index at age 20. Conversely, the fasting glucose concentration increased by 6% (-1% to 13%) for each doubling in PCB. Similar associations were seen in subjects without impaired fasting glycemia, while further adjustment for current body mass index and lipid metabolism parameters attenuated some of the associations.
CONCLUSIONS: Impaired insulin secretion appears to constitute an important part of the type 2 diabetes pathogenesis associated with exposure to persistent lipophilic food contaminants.
Authors:
Philippe Grandjean; Jan Erik Henriksen; Anna L Choi; Maria Skaalum Petersen; Christine Dalgård; Flemming Nielsen; Pal Weihe
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  22     ISSN:  1531-5487     ISO Abbreviation:  Epidemiology     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-05     Completed Date:  2011-08-16     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  410-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Distribution
Aged
Blood Glucose / analysis
Confidence Intervals
Cross-Sectional Studies
Diabetes Mellitus, Type 2 / blood*,  diagnosis
Environmental Exposure / adverse effects
Female
Follow-Up Studies
Food Chain
Food Contamination*
Humans
Incidence
Insulin / blood*
Male
Norway
Odds Ratio
Polychlorinated Biphenyls / adverse effects,  blood*
Risk Assessment
Seafood / adverse effects*
Sex Distribution
Grant Support
ID/Acronym/Agency:
ES013692/ES/NIEHS NIH HHS; P30 ES000002/ES/NIEHS NIH HHS; R01 ES013692/ES/NIEHS NIH HHS; R01 ES013692-01A2/ES/NIEHS NIH HHS; R01 ES013692-02/ES/NIEHS NIH HHS; R01 ES013692-03/ES/NIEHS NIH HHS; R01 ES013692-04/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Insulin; DFC2HB4I0K/Polychlorinated Biphenyls
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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