Document Detail


Marginal zinc deficiency in rats decreases leptin expression independently of food intake and corticotrophin-releasing hormone in relation to food intake.
MedLine Citation:
PMID:  17475084     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Zn deficiency reduces food intake and growth rate in rodents. To determine the relationship between Zn deficiency and the regulation of food intake, we evaluated leptin gene expression in epididymal white adipose tissue (eWAT), and hypothalamic corticotropin-releasing hormone (hCRH) and hypothalamic neuropeptide Y (hNPY) of rats Zn-deficient only to show reduced food intake and growth rate but not food intake cycling. Growing male Sprague-Dawley rats (240 g) were randomly assigned to one of four dietary groups: Zn-adequate (ZA; 30 mg/kg diet), Zn-deficient (ZD; 3 mg/kg diet), pair-fed with ZD (PF; 30 mg/kg diet) and Zn-sufficient (ZS; 50 mg/kg diet) (n 8), and were fed for 3 weeks. Food intake and body weight were measured, as were blood mononuclear cells and pancreas Zn levels. eWAT leptin, hCRH and hNPY mRNA levels were determined. Food intake was decreased by about 10 % in ZD and PF rats compared to ZA and ZS rats. Growth and eWAT leptin mRNA levels were unaffected in PF rats but were significantly (P < 0.05) decreased in ZD rats. However, hNPY showed a tendency to increase, and hCRH significantly (P < 0.05) decreased, in both ZD and PF rats. These results suggest that while leptin gene expression may be directly affected by Zn, hNPY and hCRH are likely responding to reduced food intake caused by Zn deficiency.
Authors:
In-Sook Kwun; Young-Eun Cho; Ria-Ann R Lomeda; Soon-Tae Kwon; Yangha Kim; John H Beattie
Related Documents :
7816884 - Nucleus accumbens dopamine release increases during instrumental lever pressing for foo...
17878674 - Distinct effects of anterior pyriform cortex and the lateral hypothalamus lesions on pr...
20004704 - The suprachiasmatic nucleus participates in food entrainment: a lesion study.
3212064 - Effects of food temperature and ambient temperature during a meal on food intake in the...
1117374 - Fine structure of possible photoreceptor in cercariae of schistosoma mansoni.
11704564 - Food restriction prevents age-related polyuria by vasopressin-dependent recruitment of ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  98     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-25     Completed Date:  2007-10-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  485-9     Citation Subset:  IM    
Affiliation:
Department of Food Science and Nutrition, Andong National University, Andong, Kyungpook, 760-749, South Korea. iskwun@andong.ac.kr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adipose Tissue, White / chemistry
Animals
Appetite Regulation / physiology*
Corticotropin-Releasing Hormone / analysis*
Diet
Epididymis / chemistry
Gene Expression / genetics
Hypothalamus / chemistry
Leptin / genetics*
Male
Neuropeptide Y / analysis
RNA, Messenger / analysis
Rats
Rats, Sprague-Dawley
Weight Gain / physiology
Zinc / administration & dosage,  analysis,  deficiency*
Chemical
Reg. No./Substance:
0/Leptin; 0/Neuropeptide Y; 0/RNA, Messenger; 7440-66-6/Zinc; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Bioavailability and antioxidant capacity of plant extracts rich in polyphenols, given as a single ac...
Next Document:  Effect of hyperbaric oxygen and vitamin C and E supplementation on biomarkers of oxidative stress in...