Document Detail


Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women.
MedLine Citation:
PMID:  22955512     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous animal studies showed that severe vitamin B-6 deficiency altered fatty acid profiles of tissue lipids, often with an increase of linoleic acid and a decrease of arachidonic acid. However, little is known about the extent to which vitamin B-6 deficiency affects human fatty acid profiles. The aim of this study was to determine the effects of marginal vitamin B-6 deficiency on fatty acid profiles in plasma, erythrocytes, and peripheral blood mononuclear cells (PBMC) of healthy adults fed a 28-d, low-vitamin B-6 diet. Healthy participants (n = 23) received a 2-d, controlled, vitamin B-6-adequate diet followed by a 28-d, vitamin B-6-restricted diet to induce a marginal deficiency. Plasma HDL and LDL cholesterol concentrations, FFA concentrations, and erythrocyte and PBMC membrane fatty acid compositions did not significantly change from baseline after the 28-d restriction. Plasma total arachidonic acid, EPA, and DHA concentrations decreased from (mean ± SD) 548 ± 96 to 490 ± 94 μmol/L, 37 ± 13 to 32 ± 13 μmol/L, and 121 ± 28 to 109 ± 28 μmol/L [positive false discovery rate (pFDR) adjusted P < 0.05], respectively. The total (n-6):(n-3) PUFA ratio in plasma exhibited a minor increase from 15.4 ± 2.8 to 16.6 ± 3.1 (pFDR adjusted P < 0.05). These data indicate that short-term vitamin B-6 restriction decreases plasma (n-3) and (n-6) PUFA concentrations and tends to increase the plasma (n-6):(n-3) PUFA ratio. Such changes in blood lipids may be associated with the elevated risk of cardiovascular disease in vitamin B-6 insufficiency.
Authors:
Mei Zhao; Yvonne Lamers; Maria A Ralat; Bonnie S Coats; Yueh-Yun Chi; Keith E Muller; James R Bain; Meena N Shankar; Christopher B Newgard; Peter W Stacpoole; Jesse F Gregory
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-09-05
Journal Detail:
Title:  The Journal of nutrition     Volume:  142     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-21     Completed Date:  2012-12-03     Revised Date:  2013-10-09    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1791-7     Citation Subset:  IM    
Affiliation:
Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, niversity of Florida, Gainesville, FL, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Arachidonic Acid / blood*
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Diet
Docosahexaenoic Acids / blood*
Eicosapentaenoic Acid / blood*
Erythrocyte Membrane / chemistry
Erythrocytes / chemistry,  drug effects
Fatty Acids, Omega-6 / blood*
Female
Humans
Leukocytes, Mononuclear / chemistry,  drug effects
Male
Questionnaires
Vitamin B 6 / administration & dosage
Vitamin B 6 Deficiency / blood,  physiopathology*
Young Adult
Grant Support
ID/Acronym/Agency:
1UL1RR029890/RR/NCRR NIH HHS; R01 DK072398/DK/NIDDK NIH HHS; R01 DK072398/DK/NIDDK NIH HHS; UL1 TR000064/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Fatty Acids, Omega-6; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid; 8059-24-3/Vitamin B 6
Comments/Corrections

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