Document Detail


Marfan syndrome and mitral valve prolapse.
MedLine Citation:
PMID:  15578086     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mitral valve prolapse (MVP), an abnormal displacement into the left atrium of a thickened and redundant mitral valve during systole, is a relatively frequent abnormality in humans and may be associated with serious complications. A recent study implicates fibrillin-1, a component of extracellular matrix microfibrils, in the pathogenesis of a murine model of MVP. This investigation represents an initial step toward understanding the mechanisms involved in human MVP disease and the development of potential treatments.
Authors:
Arthur E Weyman; Marielle Scherrer-Crosbie
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  114     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-03     Completed Date:  2005-02-08     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1543-6     Citation Subset:  AIM; IM    
Affiliation:
Cardiac Ultrasound Laboratory, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. aweyman@partners.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Marfan Syndrome / genetics*,  pathology
Mice
Microfilament Proteins / genetics,  metabolism
Mitral Valve Prolapse / pathology,  physiopathology*
Transforming Growth Factor beta / metabolism
Chemical
Reg. No./Substance:
0/Microfilament Proteins; 0/Transforming Growth Factor beta; 0/fibrillin
Comments/Corrections
Comment On:
J Clin Invest. 2004 Dec;114(11):1586-92   [PMID:  15546004 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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