Document Detail

Marchiafava-Bignami disease: literature review and case report.
MedLine Citation:
PMID:  10645739     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We postulated that disruption of callosal pathways as occurs in Marchiafava-Bignami disease (MBD) is associated with marked impairment in brain functioning as measured by cognitive assessment and neuroimaging. BACKGROUND: MBD is considered to be a rare and severe complication of chronic alcoholism. It is characterized by necrosis and subsequent atrophy of the corpus callosum, which is the major brain structure connecting corresponding areas of both hemispheres. METHODS: We review the existing literature on MBD with respect to conceptualization, theories of pathogenesis, forms of the disease, and neuroimaging and neuropsychological findings. We then present the case of a middle-aged man with MBD who underwent extensive clinical, neuropsychological, and neuroimaging studies. RESULTS: Neuropsychological evaluation revealed a pattern of severe global dementia. Magnetic resonance imaging showed moderate atrophy of anterior callosal regions and severe atrophy of posterior callosal regions in the setting of cortical and subcortical atrophy. Resting metabolism positron emission tomography revealed decreased glucose metabolism most pronounced in subcortical and mesial frontal regions. The differential diagnosis, function of the corpus callosum, and potential limitations of our case study are discussed. CONCLUSIONS: On account of the history, clinical presentation, and results of magnetic resonance imaging of the brain, we diagnosed our patient with chronic MBD.
C G Kohler; B M Ances; A R Coleman; J D Ragland; M Lazarev; R C Gur
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Neuropsychiatry, neuropsychology, and behavioral neurology     Volume:  13     ISSN:  0894-878X     ISO Abbreviation:  Neuropsychiatry Neuropsychol Behav Neurol     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-02-18     Completed Date:  2000-02-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8811108     Medline TA:  Neuropsychiatry Neuropsychol Behav Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  67-76     Citation Subset:  IM    
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104-4283, USA.
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MeSH Terms
Alcohol-Related Disorders / diagnosis,  physiopathology*
Corpus Callosum / drug effects*,  pathology,  physiopathology
Ethanol / adverse effects
Magnetic Resonance Imaging*
Middle Aged
Neuropsychological Tests*
Tomography, Emission-Computed*
Grant Support
Reg. No./Substance:

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