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Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines.
MedLine Citation:
PMID:  21241017     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Within a mammalian organism, the interaction among cells both at short and long distances is mediated by soluble factors released by cells into the extracellular environment. The secreted proteins may involve extracellular matrix proteins, proteinases, growth factors, protein hormones, immunoregulatory cytokines, chemokines or other bioactive molecules that have a direct impact on target cell phenotype. Stem cells of mesenchymal, adipose, neural and embryonic origin, fibroblast feeder cells as well as primary isolates of astrocytes, endothelial and muscle cells have recently become targets of intensive secretome profiling with the search for proteins regulating cell survival, proliferation, differentiation or inflammatory response. Recent advances and challenges of the stem cell and primary cell secretome analysis together with the most relevant results are discussed in this review.
Authors:
Helena Skalnikova; Jan Motlik; Suresh Jivan Gadher; Hana Kovarova
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Publication Detail:
Type:  Journal Article     Date:  2011-01-17
Journal Detail:
Title:  Proteomics     Volume:  11     ISSN:  1615-9861     ISO Abbreviation:  Proteomics     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101092707     Medline TA:  Proteomics     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  691-708     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Libechov, Czech Republic.
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