| Mapping the road to resilience: novel math for the study of frailty. | |
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MedLine Citation:
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PMID: 18929593 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Frailty stands at the nexus of geriatrics and gerontology, and requires both basic biology and clinical knowledge for its analysis. Understanding frailty difficulties much more than simply adding another outcome measure in epidemiological studies. The major challenge is the identification of multiple feed-forward and feed-back signaling pathways involved in the maintenance of biological homeostasis in complex organisms that may fail with aging. The cause of frailty and loss of resilience is probably a progressive loss of redundancy in these response patterns and connections. Advances toward the development of a theoretical model that can potentially embrace the complexity of frailty should be highly encouraged, especially models designed to explain the biology of aging which can promote a better integration and communication between scientists who study this problem from different perspectives. |
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Authors:
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Luigi Ferrucci; Francesco Giallauria; David Schlessinger |
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Publication Detail:
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Type: Comment; Journal Article Date: 2008-09-25 |
Journal Detail:
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Title: Mechanisms of ageing and development Volume: 129 ISSN: 0047-6374 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-12-08 Completed Date: 2009-03-05 Revised Date: 2010-09-21 |
Medline Journal Info:
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Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: Ireland |
Other Details:
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Languages: eng Pagination: 677-9 Citation Subset: IM |
Affiliation:
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Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, United States. ferruccilu@grc.nia.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Aging / physiology* Biological Markers / metabolism Disease Susceptibility* Feedback, Physiological Frail Elderly* Homeostasis Humans Models, Biological* Phenotype Reproducibility of Results Stress, Physiological* Systems Biology* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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Z01 AG000971-01/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
| Comments/Corrections | |
Comment On:
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Mech Ageing Dev. 2008 Nov;129(11):666-70
[PMID:
18938195
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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