| Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. | |
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MedLine Citation:
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PMID: 8040284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A genetic map for rat chromosome 2 that includes five candidate genes for blood pressure regulation was constructed in a region containing a quantitative trait locus (QTL) for blood pressure. Two F2 populations of male rats raised on high salt (8% NaCI) diet from weaning were studied: F2(WKY x S), derived from a cross of Dahl salt-sensitive rats (S) and Wistar-Kyoto rats (WKY); and F2(MNS x S), derived from a cross of S rats and Milan normotensive strain (MNS). In both populations a blood pressure QTL was localized between Na+,K(+)-ATPase alpha 1 isoform and calmodulin-dependent protein kinase II-delta loci. The LOD score for existence of this blood pressure QTL based on the combined populations (n = 330) was 5.66 and accounted for 9.2% of the total variance and 26% of the genetic variance. |
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Authors:
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A Y Deng; H Dene; J P Rapp |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 94 ISSN: 0021-9738 ISO Abbreviation: J. Clin. Invest. Publication Date: 1994 Jul |
Date Detail:
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Created Date: 1994-08-19 Completed Date: 1994-08-19 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 431-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/U01223; U01224; U01225; U01226 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Blood Pressure* Calcium-Calmodulin-Dependent Protein Kinases / genetics Chromosome Mapping* Female Male Molecular Sequence Data Rats / genetics* Rats, Inbred WKY Sodium-Potassium-Exchanging ATPase / genetics |
| Chemical | |
Reg. No./Substance:
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EC 2.7.11.17/Calcium-Calmodulin-Dependent Protein Kinases; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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