Document Detail

Mapping quantitative trait Loci for left-sided displacement of the abomasum in German Holstein dairy cows.
MedLine Citation:
PMID:  18946144     Owner:  NLM     Status:  MEDLINE    
A whole-genome scan using an affected paternal half-sib design was utilized to detect quantitative trait loci (QTL) for left-sided displaced abomasum (LDA) in German Holsteins. A total of 360 animals from 14 paternal half-sib families were genotyped, for a total of 306 polymorphic microsatellites. For a whole-genome scan, 221 markers were equally distributed over all 29 bovine autosomes, with an average distance of 13.7 cM. For fine-mapping, a total of 85 additional microsatellites were used. We identified genome-wide significant QTL on Bos taurus autosome (BTA) 1 (54.6 to 58.3 cM) and on BTA3 (5.9 cM). Furthermore, 3 chromosome-wide significant QTL were located on bovine chromosomes 21, 23, and 24. In addition, we found 11 QTL that cosegregated in grandsire families but that were not significant in the across-family analysis. These QTL were located on BTA5, 6, 10, 12, 15, 16, 17, 19, 23, and 26. This study is the first report on QTL for LDA and is a first step toward identifying single nucleotide polymorphisms for LDA-QTL.
S Mömke; H Scholz; K Doll; J Rehage; O Distl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of dairy science     Volume:  91     ISSN:  1525-3198     ISO Abbreviation:  J. Dairy Sci.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-23     Completed Date:  2009-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985126R     Medline TA:  J Dairy Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4383-92     Citation Subset:  IM    
Institute for Animal Breeding and Genetics, University for Veterinary Medicine Hannover, 30559 Hannover, Germany.
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MeSH Terms
Abomasum / abnormalities*
Cattle Diseases / genetics*
Chromosome Mapping*
Genome / genetics
Microsatellite Repeats / genetics
Quantitative Trait Loci / genetics*
Stomach Diseases / genetics,  veterinary*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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