| Mapping of obesity QTLs in a cross between mouse lines divergently selected on fat content. | |
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MedLine Citation:
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PMID: 10602985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A genome-wide quantitative trait locus (QTL) analysis was performed in a polygenic obesity mouse model resulting from a long-term selection experiment. The parental lines were outbred lines divergently selected for 53 generations for high-fat (fat, F line) or low-fat (lean, L line) percentage (fat%) that differed fivefold in fat% at 14 weeks of age. An F2 population of 436 mice was used for the QTL analysis with 71 markers distributed across the genome. The analysis revealed significant QTLs Fob1 (for F-line obesity QTL 1), Fob2, Fob3, and Fob4, on Chromosomes (Chrs) 2, 12, 15, and X, respectively. None of these QTLs map to regions of known single gene obesity mutations (Lepob, Leprdb, Cpefat, Ay, tub), though they map to regions of previously described obesity QTLs and candidate genes. The effects of Fob1, Fob3, Fob4 were additive, and that of Fob2 was dominant. Fob2 also showed a significant female-specific effect. Fob1, Fob2, Fob3, and Fob4 explained 4.9%, 19.5%, 14.4%, and 7.3% of the F2 phenotypic variance for fat%, respectively. This study identified four loci that contributed to the response to divergent selection and control a significant proportion of the difference in obesity between the F and L lines. |
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Authors:
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S Horvat; L Bünger; V M Falconer; P Mackay; A Law; G Bulfield; P D Keightley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mammalian genome : official journal of the International Mammalian Genome Society Volume: 11 ISSN: 0938-8990 ISO Abbreviation: Mamm. Genome Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-02-03 Completed Date: 2000-02-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9100916 Medline TA: Mamm Genome Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2-7 Citation Subset: IM |
Affiliation:
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Roslin Institute (Edinburgh), Division of Molecular Biology, Roslin EH25 9PS, Scotland, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromosome Mapping* Crosses, Genetic DNA / chemistry Disease Models, Animal* Electrophoresis, Agar Gel Female Male Mice Mice, Inbred ICR Obesity / genetics* Polymerase Chain Reaction Quantitative Trait, Heritable* Sequence Analysis, DNA |
| Chemical | |
Reg. No./Substance:
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9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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