| Mapping markers linked to porcine salmonellosis susceptibility. | |
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MedLine Citation:
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PMID: 19496771 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The goal of this study was to identify pig chromosomal regions associated with susceptibility to salmonellosis. Genomic DNA from pig reference populations with differences in susceptibility to Salmonella enterica serovar Choleraesuis as quantified by spleen and liver bacterial colonization at day 7 post-infection (dpi; Van Diemen et al. 2002) was used. These samples belonged to the offspring of a sire thought to be heterozygous for genes involved in susceptibility to salmonellosis. Amplified fragment length polymorphism (AFLP) markers were created and used to determine associations with spleen or bacterial counts at 7 dpi. To position linked markers, two mapping populations, the Roslin and Uppsala PiGMaP pedigrees were used to create an integrated map which included the AFLP markers associated with salmonellosis. Twenty-six AFLP markers located in 14 different chromosomal regions in the porcine genome were found to be significantly associated with susceptibility (Chi-square P < 0.05). More than one linked marker was found on chromosomes 1, 7, 13, 14 and 18. It is likely that these regions contain genes involved in Salmonella susceptibility. Regions on chromosomes 1, 7 and 14 were significantly associated with Salmonella counts in the liver and regions on chromosomes 11, 13 and 18 with counts in spleen. The identification of these chromosomal regions highlights specific areas to search for candidate genes that may be involved in innate or adaptive immunity. Further investigation into these chromosomal regions would be useful to improve our understanding of host responses to infection with this widespread pathogen. |
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Authors:
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L Galina-Pantoja; K Siggens; M G M van Schriek; H C M Heuven |
Publication Detail:
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Type: Journal Article Date: 2009-06-03 |
Journal Detail:
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Title: Animal genetics Volume: 40 ISSN: 1365-2052 ISO Abbreviation: Anim. Genet. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-07-05 Completed Date: 2010-08-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8605704 Medline TA: Anim Genet Country: England |
Other Details:
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Languages: eng Pagination: 795-803 Citation Subset: IM |
Affiliation:
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PIC/Genus, 100 Bluegrass Commons Blvd, Hendersonville, TN 37075, USA. Lucina.Galina@pic.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amplified Fragment Length Polymorphism Analysis Animals Female Genetic Markers Genetic Predisposition to Disease* Male Salmonella Infections, Animal / genetics* Salmonella enterica Sus scrofa Swine Diseases / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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