Document Detail


Mapping kainate activation of inner neurons in the rat retina.
MedLine Citation:
PMID:  23348566     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Kainate receptors mediate fast, excitatory synaptic transmission for a range of inner neurons in the mammalian retina. However, allocation of functional kainate receptors to known cell types and their sensitivity remains unresolved. Using the cation channel probe 1-amino-4-guanidobutane agmatine (AGB), we investigated kainate sensitivity of neurochemically identified cell populations within the structurally intact rat retina. Most inner retinal neuron populations responded to kainate in a concentration-dependent manner. OFF cone bipolar cells demonstrated the highest sensitivity of all inner neurons to kainate. Immunocytochemical localization of AGB and macromolecular markers confirmed that type 2 bipolar cells were part of this kainate-sensitive population. The majority of amacrine (ACs) and ganglion cells (GCs) showed kainate responses with different sensitivities between major neurochemical classes (γ-aminobutyric acid [GABA]/glycine ACs > glycine ACs > GABA ACs; glutamate [Glu]/weakly GABA GCs > Glu GCs). Conventional and displaced cholinergic ACs were highly responsive to kainate, whereas dopaminergic ACs do not appear to express functional kainate receptors. These findings further contribute to our understanding of neuronal networks in complex multicellular tissues.
Authors:
Lisa Nivison-Smith; Daniel Sun; Erica L Fletcher; Robert E Marc; Michael Kalloniatis
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  521     ISSN:  1096-9861     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-06-05     Completed Date:  2014-01-13     Revised Date:  2014-06-09    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2416-38     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Agmatine / pharmacology
Amacrine Cells / drug effects
Animals
Brain Mapping / methods*
Dose-Response Relationship, Drug
Fluorescent Antibody Technique, Indirect
GABA Agonists / pharmacology*
Glutamic Acid / metabolism
Glycine / metabolism
Immunohistochemistry
Kainic Acid / pharmacology*
Male
Neurons / drug effects,  physiology*
Rats
Rats, Sprague-Dawley
Retina / cytology,  drug effects,  physiology*
Retinal Bipolar Cells / drug effects,  physiology
Retinal Ganglion Cells / drug effects,  physiology
Tissue Embedding / methods
gamma-Aminobutyric Acid / metabolism
Grant Support
ID/Acronym/Agency:
EY014800/EY/NEI NIH HHS; EY02576/EY/NEI NIH HHS; P30 EY014800/EY/NEI NIH HHS; R01 EY002576/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/GABA Agonists; 3KX376GY7L/Glutamic Acid; 56-12-2/gamma-Aminobutyric Acid; 70J407ZL5Q/Agmatine; SIV03811UC/Kainic Acid; TE7660XO1C/Glycine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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