| Mapping of inflammatory bowel disease in northern France: spatial variations and relation to affluence. | |
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MedLine Citation:
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PMID: 19774647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Geographic variations in the incidence of inflammatory bowel disease (IBD) may reflect variations in the distribution of environmental etiologic factors. We assessed spatial variation in the incidence of IBD in northern France and analyzed its association with a deprivation index. METHODS: All cases of IBD included in the EPIMAD registry between 1990 and 2003 were extracted. The standardized incidence ratio (SIR) was calculated for each canton in the region. The association between incidence and deprivation was assessed using the Townsend deprivation index. RESULTS: The mean annual incidence rates of Crohn's disease (CD) and ulcerative colitis (UC) were 6.2 x 10(-5) and 3.8 x 10(-5), respectively. The mean cumulative numbers of cases by canton were 18.4 (1-183) for CD and 11.3 (0-148) for UC. For both CD and UC, mapping depicted spatial heterogeneity in the SIR with spatial autocorrelation. A high relative risk (RR) of CD was observed in mainly rural and periurban cantons of the region. For UC, a high RR was found in cantons of the south and the center of Pas-de-Calais. No significant correlation was observed between spatial variations in IBD and deprivation. CONCLUSIONS: The incidence of IBD is associated with spatial heterogeneity in northern France. The noteworthy predominance of CD in agricultural areas warrants further investigations. |
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Authors:
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Christophe Declercq; Corinne Gower-Rousseau; Gwénola Vernier-Massouille; Julia Salleron; Mamadou Baldé; Gilles Poirier; Eric Lerebours; Jean Louis Dupas; Véronique Merle; Raymond Marti; Alain Duhamel; Antoine Cortot; Jean-Louis Salomez; Jean-Frédéric Colombel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Inflammatory bowel diseases Volume: 16 ISSN: 1536-4844 ISO Abbreviation: Inflamm. Bowel Dis. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-19 Completed Date: 2010-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508162 Medline TA: Inflamm Bowel Dis Country: United States |
Other Details:
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Languages: eng Pagination: 807-12 Citation Subset: IM |
Affiliation:
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Observatoire Régional de la Santé Nord-Pas de Calais, Loos, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Colitis, Ulcerative / epidemiology* Crohn Disease / epidemiology* Female France / epidemiology Genetics, Population Geography Humans Incidence Male Prognosis Socioeconomic Factors Young Adult |
| Comments/Corrections | |
Comment In:
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Inflamm Bowel Dis. 2010 May;16(5):804-6
[PMID:
19753639
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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