Document Detail

Mapping immunoglobulin gene-related DNA probes to the central region of normal and pericentrically inverted human chromosome 2.
MedLine Citation:
PMID:  8314587     Owner:  NLM     Status:  MEDLINE    
Several immunoglobulin kappa-related sequences were transposed in evolution from the short arm to the long arm of chromosome 2. The common pericentric inversion of this chromosome found in present-day populations results in an apparent reinversion of those sequences to the short arm and the transposition of the kappa and CD8 alpha loci to the long arm. This is shown by in situ hybridization and PFGE experiments with hybridization probes from both arms of chromosome 2, i.e., from 2cen-p12 and 2cen-q13. The inversion breakpoints lie outside of all hybridization sites, and the inversion is described as inv(2)(p12q14). The possibility of common breakpoints in ancient and present-day pericentric inversions is discussed.
A Lautner-Rieske; H Hameister; G Barbi; H G Zachau
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genomics     Volume:  16     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-07-26     Completed Date:  1993-07-26     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  497-502     Citation Subset:  IM    
Institut für Physiologische Chemie, Universität München, Germany.
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MeSH Terms
Chromosome Inversion*
Chromosome Mapping
Chromosomes, Human, Pair 2*
Cloning, Molecular
DNA Probes*
Electrophoresis, Gel, Pulsed-Field
Genes, Immunoglobulin*
Immunoglobulin Constant Regions / genetics
Immunoglobulin kappa-Chains / genetics
In Situ Hybridization
Reg. No./Substance:
0/DNA Probes; 0/Immunoglobulin Constant Regions; 0/Immunoglobulin kappa-Chains

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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