| Mapping of hypothalamic sites involved in the effects of NPY on body temperature and food intake. | |
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MedLine Citation:
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PMID: 7895089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of the present study was to identify hypothalamic sites that might be implicated in the effects of neuropeptide Y (NPY) on both body temperature and food intake. For this purpose, the effects of direct microinjections of NPY in several doses (0.156-20 micrograms) into discrete hypothalamic nuclei on body temperature were examined in rats. To examine specificity of effects, food consumption of animals following injections was also measured. Results indicate that the influence of NPY on body temperature varies with the hypothalamic region where the peptide is administered. NPY had no effect on temperature after administration into the ventromedial (VMH) and the perifornical hypothalamus (PeF). However, a significant hypothermia was seen following administration into the preoptic (POA) and arcuate nucleus (Arc), and hyperthermia was seen after injection into the paraventricular nucleus (PVN). Finally, a biphasic effect was observed after injection into the lateral hypothalamus (LH): hyperthermia with relatively small doses and hypothermia with higher doses. Similar effects were obtained when administered into the third ventricle (3V) but in an inverted dose-related fashion: hypothermia at low and hyperthermia at higher doses. For feeding, NPY consistently increased food intake in all regions examined, with the strongest effect obtained after administration into the PeF. The present results clearly dissociate the effects of NPY on food intake and body temperature, and demonstrate that these effects are related to specific hypothalamic nuclei. |
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Authors:
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F B Jolicoeur; S M Bouali; A Fournier; S St-Pierre |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research bulletin Volume: 36 ISSN: 0361-9230 ISO Abbreviation: Brain Res. Bull. Publication Date: 1995 |
Date Detail:
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Created Date: 1995-04-24 Completed Date: 1995-04-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 125-9 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Faculty of Medicine, University of Sherbrooke, Québec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature / drug effects* Brain Mapping* Eating / drug effects* Hypothalamus / physiology* Male Microinjections Neuropeptide Y / pharmacology* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptide Y |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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