Document Detail

Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker.
MedLine Citation:
PMID:  9803267     Owner:  NLM     Status:  MEDLINE    
We have identified a highly polymorphic intragenic marker composed of two dinucleotide repeats in an intron of the human interferon regulatory factor (IRF3) gene. This polymorphic marker has allowed us to map IRF3 to the boundary of 19q13.3-13.4 between the polymorphic markers D19S604 and D19S206 close to KLK1. An intron is present in a homologous position in the mouse Irf3 gene, but lacks the dinucleotide repeats present in the human intron. Syntenic conservation between this region of 19q13.3-13.4 maps Irf3 to either mouse chromosome 7 or 17.
J Bellingham; K Gregory-Evans; C Y Gregory-Evans
Related Documents :
8754257 - Genetic polymorphism of the 3' vntr region of the human dopaminergic function gene dat1...
17039477 - Inbreeding from isonymy and repeated pairs of surnames in the ebro delta region (tarrag...
18752197 - Comparison of maize similarity and dissimilarity genetic coefficients based on microsat...
1639377 - Mapping the human liver/islet glucose transporter (glut2) gene within a genetic linkage...
3162827 - Philadelphia chromosome-positive acute lymphoblastic leukemia cell lines without classi...
9515797 - A distinct region of chromosome 19p13.3 associated with the sporadic form of adenoma ma...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of human genetics     Volume:  62     ISSN:  0003-4800     ISO Abbreviation:  Ann. Hum. Genet.     Publication Date:  1998 May 
Date Detail:
Created Date:  1999-01-07     Completed Date:  1999-01-07     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  0416661     Medline TA:  Ann Hum Genet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  231-4     Citation Subset:  IM    
Department of Molecular Genetics, Imperial College School of Medicine, London, UK.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AF036341;  U86636
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amino Acid Sequence
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 19*
DNA, Complementary
DNA-Binding Proteins / genetics*
Gene Frequency
Genetic Markers
Interferon Regulatory Factor-3
Molecular Sequence Data
Polymorphism, Genetic*
Transcription Factors / genetics*
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/DNA, Complementary; 0/DNA-Binding Proteins; 0/Genetic Markers; 0/IRF3 protein, human; 0/Interferon Regulatory Factor-3; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  C73R is a hotspot mutation in the uroporphyrinogen III synthase gene in congenital erythropoietic po...
Next Document:  Increased parental age and number of pregnancies in Klippel-Trenaunay-Weber syndrome.