Document Detail


Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker.
MedLine Citation:
PMID:  9803267     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have identified a highly polymorphic intragenic marker composed of two dinucleotide repeats in an intron of the human interferon regulatory factor (IRF3) gene. This polymorphic marker has allowed us to map IRF3 to the boundary of 19q13.3-13.4 between the polymorphic markers D19S604 and D19S206 close to KLK1. An intron is present in a homologous position in the mouse Irf3 gene, but lacks the dinucleotide repeats present in the human intron. Syntenic conservation between this region of 19q13.3-13.4 maps Irf3 to either mouse chromosome 7 or 17.
Authors:
J Bellingham; K Gregory-Evans; C Y Gregory-Evans
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of human genetics     Volume:  62     ISSN:  0003-4800     ISO Abbreviation:  Ann. Hum. Genet.     Publication Date:  1998 May 
Date Detail:
Created Date:  1999-01-07     Completed Date:  1999-01-07     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  0416661     Medline TA:  Ann Hum Genet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  231-4     Citation Subset:  IM    
Affiliation:
Department of Molecular Genetics, Imperial College School of Medicine, London, UK. jbelling@hgmp.mrc.ac.uk
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AF036341;  U86636
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MeSH Terms
Descriptor/Qualifier:
Alleles
Amino Acid Sequence
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 19*
DNA, Complementary
DNA-Binding Proteins / genetics*
Gene Frequency
Genetic Markers
Humans
Interferon Regulatory Factor-3
Molecular Sequence Data
Polymorphism, Genetic*
Transcription Factors / genetics*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/DNA, Complementary; 0/DNA-Binding Proteins; 0/Genetic Markers; 0/IRF3 protein, human; 0/Interferon Regulatory Factor-3; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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