Document Detail


Mapping the human amylase gene cluster on the proximal short arm of chromosome 1 using a highly informative (CA)n repeat.
MedLine Citation:
PMID:  1692298     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human amylase gene cluster includes a (CA)n repeat sequence immediately upstream of the gamma-actin pseudogene associated with the AMY2B gene. Analysis of this (CA)n repeat by PCR amplification of genomic DNA from the 40 families of the Centre d'Etude du Polymorphisme Humain (CEPH) reference panel revealed extensive polymorphism. A total of six alleles with (CA)n lengths of 16-21 repeats were found. The average heterozygosity for this polymorphism was 0.70. Multipoint linkage analysis showed that the amylase gene cluster is located distal to the nerve growth factor beta-subunit gene (NGFB) and is within 1 cM of the anonymous locus D1S10. The amylase (CA)n repeat provides a convenient marker for both the physical and the genetic maps of human chromosome 1p.
Authors:
N C Dracopoli; M H Meisler
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  7     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-06-08     Completed Date:  1990-06-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  97-102     Citation Subset:  IM    
Affiliation:
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Amylases / genetics*
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 1*
Female
Humans
Linkage (Genetics)
Lod Score
Male
Molecular Sequence Data
Multigene Family*
Pedigree
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Repetitive Sequences, Nucleic Acid*
Grant Support
ID/Acronym/Agency:
CA-44176/CA/NCI NIH HHS; GM-24872/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
EC 3.2.1.-/Amylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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