Document Detail

Mapping of fertility traits in Finnish Ayrshire by genome-wide association analysis.
MedLine Citation:
PMID:  21554346     Owner:  NLM     Status:  In-Data-Review    
A whole-genome scan using single marker association was used to detect chromosome regions associated with seven female fertility traits in Finnish Ayrshire dairy cattle. The phenotypic data consisted of de-regressed estimated breeding values for 340 bulls which were estimated using a single trait model. Genotypes were obtained with the Illumina BovineSNP50 panel and a total of 35 630 informative, high-quality single nucleotide polymorphism (SNP) markers were used. The association analysis was performed using a mixed-model approach which fitted a fixed effect for each SNP and a random polygenic effect. We detected eleven genome-wide significant associations on eight different chromosomes. With at least chromosome-wise significance after Bonferroni correction, sixteen SNPs on nine chromosomes showed significant associations with one or more fertility traits. The results confirmed quantitative trait loci on three chromosomes (1, 2 and 20) for fertility traits previously reported for the same breed and one on chromosome four previously detected in Holstein cattle.
N F Schulman; G Sahana; T Iso-Touru; S D McKay; R D Schnabel; M S Lund; J F Taylor; J Virta; J H Vilkki
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Publication Detail:
Type:  Journal Article     Date:  2011-01-17
Journal Detail:
Title:  Animal genetics     Volume:  42     ISSN:  1365-2052     ISO Abbreviation:  Anim. Genet.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8605704     Medline TA:  Anim Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  263-9     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors, Animal Genetics © 2011 Stichting International Foundation for Animal Genetics.
MTT, Agrifood Research Finland, Biotechnology and Food Research, FIN-31600 Jokioinen, Finland. Aarhus University, Faculty of Agricultural Sciences, Department of Genetics and Biotechnology, Research Centre Foulum, DK-8830 Tjele, Denmark. University of Missouri, Division of Animal Sciences, Columbia, MO 65211, USA.
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