| Mapping cortical morphology in youth with velocardiofacial (22q11.2 deletion) syndrome. | |
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MedLine Citation:
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PMID: 21334567 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Velocardiofacial syndrome (VCFS; 22q11.2 deletion syndrome) represents one of the highest known risk factors for schizophrenia. Insofar as up to 30% of individuals with this genetic disorder develop schizophrenia, VCFS constitutes a unique, etiologically homogeneous model for understanding the pathogenesis of schizophrenia. METHOD: Using a longitudinal, case-control design, anatomic magnetic resonance images were acquired to investigate cross-sectional and longitudinal alterations in surface cortical morphology in a cohort of adolescents with VCFS and age-matched typical controls. All participants were scanned at two time points. RESULTS: Compared with controls, youth with VCFS exhibited alterations in inferior frontal, dorsal frontal, occipital, and cerebellar brain regions at both time points. Little change was observed over time in surface morphology of either study group. However, within the VCFS group only, worsening psychosocial functioning over time was associated with time 2 surface contractions in left middle and inferior temporal gyri. Further, prodromal symptoms at time 2 were associated with surface contractions in the left and right orbitofrontal, temporal, and cerebellar regions and surface protrusions of the supramarginal gyrus. CONCLUSIONS: These findings advance the understanding of cortical disturbances in VCFS that produce vulnerability for psychosis in this high-risk population. |
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Authors:
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Wendy R Kates; Ravi Bansal; Wanda Fremont; Kevin M Antshel; Xuejun Hao; Anne Marie Higgins; Jun Liu; Robert J Shprintzen; Bradley S Peterson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-01-14 |
Journal Detail:
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Title: Journal of the American Academy of Child and Adolescent Psychiatry Volume: 50 ISSN: 1527-5418 ISO Abbreviation: J Am Acad Child Adolesc Psychiatry Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-21 Completed Date: 2011-06-30 Revised Date: 2012-03-07 |
Medline Journal Info:
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Nlm Unique ID: 8704565 Medline TA: J Am Acad Child Adolesc Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 272-282.e2 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA. KatesW@upstate.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Brain Mapping / methods* Cerebral Cortex* / pathology, physiopathology Child Chromosome Deletion* Chromosomes, Human, Pair 22* DiGeorge Syndrome* / complications, diagnosis, genetics, pathology, physiopathology, psychology Female Genetic Predisposition to Disease Humans Intelligence Tests Magnetic Resonance Imaging Male Psychiatric Status Rating Scales Risk Factors Schizophrenia* / diagnosis, etiology, pathology, physiopathology Severity of Illness Index Social Behavior Disorders / etiology, pathology, physiopathology, psychology Vulnerable Populations / psychology |
| Grant Support | |
ID/Acronym/Agency:
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MH K02-74677/MH/NIMH NIH HHS; MH64824/MH/NIMH NIH HHS; MH65481/MH/NIMH NIH HHS; R01 MH064824-10/MH/NIMH NIH HHS; R01 MH065481-03/MH/NIMH NIH HHS |
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