Document Detail


Mapping of chromosomal imbalances in pancreatic carcinoma by comparative genomic hybridization.
MedLine Citation:
PMID:  8706027     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To identify recurrent chromosomal imbalances in pancreatic adenocarcinoma, 27 tumors were analyzed by using comparative genomic hybridization. In 23 cases chromosomal imbalances were found. Gains of chromosomal material were much more frequent than losses. The most common overrepresentations were observed on chromosomes 16p (eight cases), 20q (seven cases), 22q (six cases), and 17q (five cases) and under-representations on a subregion of chromosome 9p (eight cases). Distinct high-level amplifications were found on 1p32-p34, 6q24, 7q22, 12p13, and 22q. These data provide evidence for a number of new cytogenetically defined recurrent aberrations which are characteristic of pancreatic carcinoma. The overrepresented or underrepresented chromosomal regions represent candidate regions for potential oncogenes and tumor suppressor genes, respectively, possibly involved in pancreatic tumorigenesis.
Authors:
S Solinas-Toldo; C Wallrapp; F Müller-Pillasch; M Bentz; T Gress; P Lichter
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer research     Volume:  56     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-09-10     Completed Date:  1996-09-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3803-7     Citation Subset:  IM    
Affiliation:
Deutsches Krebsforschungszentrum, Abteilung Organisation komplexer Genome, Heidelberg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / genetics*
Chromosome Aberrations*
Chromosome Mapping
Female
Genes, Tumor Suppressor
Humans
Male
Nucleic Acid Hybridization
Pancreatic Neoplasms / genetics*
Proto-Oncogenes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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