| Mapping choroidal and retinal thickness variation in Type 2 diabetes using 3D-1060nm-OCT. | |
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MedLine Citation:
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PMID: 21508108 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purpose: To map choroidal (ChT) and retinal thickness (RT) in healthy subjects and patients with diabetes with and without maculopathy using a 3D-1060nm-OCT. Methods: 63 eyes from 42 diabetic subjects (41-82 years, 11 female), grouped according to a custom scheme using ETDRS definitions: for pathology within 1 disc-diameter of fovea (without pathology (NDR), microaneurysms (M1), exudates (M2), clinically-significant-macula-edema (CSME)) and 16 eyes from 16 healthy age matched subjects (38-79 years, 11 female) were imaged by 3D-1060nm-OCT performed over 36°x36° field of view. Axial length, 45° fundus photographs, body mass index, plasma glucose and blood pressure measurements were recorded. The ChT at the subfoveal location and ChT-maps between retinal pigment epithelium and the choroidal/scleral-interface, were generated and statistically analyzed. Results: RT maps show thinning in the NDR and an increase in thickness with increasing maculopathy in the temporal and central regions (unpaired t-test P<0.05). ChT mapping of all diabetic patients demonstrated central and inferior thinning compared to healthy eyes (unpaired t-test P<0.001). Subfoveal ChT (mean±SD) for healthy eyes was 327±74μm; significantly thicker than all diabetic groups, 214±55μm for NDR, 208±49μm for M1, 205±54μm for M2, and 211±76μm for CSME (ANOVA P<0.001,Tukey P<0.001). Conclusion: 3D-1060nm-OCT has shown that the central choroid is thinner in all type 2 diabetic eyes regardless of disease stage. The choroidal thinning may exceed the magnitude of possible choriocapillaris atrophy. In contrast to the conventional assessment of pathological thickness change in several locations, thickness maps allow investigation of the choroid over the extent of affected areas. |
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Authors:
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Marieh Esmaeelpour; Boris Povazay; Boris Hermann; Bernd Hofer; Vedran Kajic; Sarah Hale; Rachel V North; Wolfgang Drexler; Nik J L Sheen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-20 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: - ISSN: 1552-5783 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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School of Optometry and Vision Sciences, Cardiff University, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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