| Mapping of the cerebral response to acetazolamide using graded asymmetric spin echo EPI. | |
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MedLine Citation:
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PMID: 16310106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebral vascular reactivity in different regions of the rat brain was quantitatively characterized by spatial and temporal measurements of blood oxygenation level-dependent (BOLD)-fMRI signals following intravenous administration of the carbonic anhydrase inhibitor acetazolamide: this causes cerebral vasodilatation through a cerebral extracellular acidosis that spares neuronal metabolism and vascular smooth muscle function, thus separating vascular and cerebral metabolic events. An asymmetric spin echo-echo planar imaging (ASE-EPI) pulse sequence sensitised images selectively to oxygenation changes in the microvasculature; use of a surface coil receiver enhanced image signal-to-noise ratios (SNRs). Image SNRs and hardware integrity were verified by incorporating quality assurance procedures; cardiorespiratory stability in the physiological preparations were monitored and maintained through the duration of the experiments. These conditions made it possible to apply BOLD contrast fMRI to map regional changes in cerebral perfusion in response to acetazolamide administration. Thus, fMRI findings demonstrated cerebral responses to acetazolamide that directly paralleled the known physiological actions of acetazolamide and whose time courses were similar through all regions of interest, consistent with acetazolamide's initial distribution in brain plasma, where it affects cerebral haemodynamics by acting at cerebral capillary endothelial cells. However, marked variations in the magnitude of the responses suggested relative perfusion deficits in the hippocampus and white matter regions correlating well with their relatively low vascularity and the known vulnerability of the hippocampus to ischaemic damage. |
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Authors:
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Bhashkar Mukherjee; Mark Preece; Gavin C Houston; Nikolas G Papadakis; T Adrian Carpenter; Laurance D Hall; Christopher L-H Huang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-11-03 |
Journal Detail:
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Title: Magnetic resonance imaging Volume: 23 ISSN: 0730-725X ISO Abbreviation: Magn Reson Imaging Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-28 Completed Date: 2006-05-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 907-20 Citation Subset: IM |
Affiliation:
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Physiological Laboratory, University of Cambridge, CB2 3EG Cambridge, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetazolamide
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pharmacokinetics,
pharmacology* Analysis of Variance Animals Carbonic Anhydrase Inhibitors / pharmacokinetics, pharmacology* Cerebrovascular Circulation / drug effects* Echo-Planar Imaging / instrumentation, methods* Image Processing, Computer-Assisted Male Rats Rats, Sprague-Dawley Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Carbonic Anhydrase Inhibitors; 59-66-5/Acetazolamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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