Document Detail


Mapping a blood pressure quantitative trait locus to a 5.7-cM region in Dahl salt-sensitive rats.
MedLine Citation:
PMID:  11331943     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A region on rat Chromosome (Chr) 2 of the Dahl salt-sensitive rat (S) was shown previously to contain a quantitative trait locus (QTL) for blood pressure (BP). This was achieved first by linkage, followed by the use of congenic strains. A congenic strain, designated S.MNS-D2Mit6/Adh, contained a segment of Chr 2 from the Milan Normotensive (MNS) rat in the S genetic background. Since the region containing the QTL was roughly 80 cM in size, a further reduction was needed towards the positional or candidate gene cloning. Currently, two congenic substrains were made from the original strain S.MNS-D2Mit6/Adh. One of these two substrains showed a BP-lowering effect, whereas the other substrain did not. Deducing the segment not shared in the two substrains, the BP QTL has to be present in a chromosome region of roughly 5.7 cM between the marker D2Rat303 and the locus for the neutroendopeptidase gene (Nep). Nep is not included within the segment. This region does not seem to contain any candidate genes well known for the BP control. Thus, the final identification of the QTL will most likely lead to the discovery of a brand new gene for the BP regulation.
Authors:
J Dutil; A Y Deng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mammalian genome : official journal of the International Mammalian Genome Society     Volume:  12     ISSN:  0938-8990     ISO Abbreviation:  Mamm. Genome     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-02     Completed Date:  2001-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100916     Medline TA:  Mamm Genome     Country:  United States    
Other Details:
Languages:  eng     Pagination:  362-5     Citation Subset:  IM    
Affiliation:
Research Centre-CHUM, Hotel Dieu, 7-132 Pavillon Jeanne Mance, 3840 rue St. Urbain, Montréal, Quebec, H2W 1T8, Canada.
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MeSH Terms
Descriptor/Qualifier:
Alcohol Dehydrogenase / genetics
Animals
Animals, Congenic
Blood Pressure / genetics*
Chromosome Mapping*
Linkage (Genetics) / genetics
Male
Quantitative Trait, Heritable*
Radiation Hybrid Mapping
Rats
Rats, Inbred Dahl
Chemical
Reg. No./Substance:
EC 1.1.1.1/Alcohol Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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