Document Detail


Mapping anatomical connectivity patterns of human cerebral cortex using in vivo diffusion tensor imaging tractography.
MedLine Citation:
PMID:  18567609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The characterization of the topological architecture of complex networks underlying the structural and functional organization of the brain is a basic challenge in neuroscience. However, direct evidence for anatomical connectivity networks in the human brain remains scarce. Here, we utilized diffusion tensor imaging deterministic tractography to construct a macroscale anatomical network capturing the underlying common connectivity pattern of human cerebral cortex in a large sample of subjects (80 young adults) and further quantitatively analyzed its topological properties with graph theoretical approaches. The cerebral cortex was divided into 78 cortical regions, each representing a network node, and 2 cortical regions were considered connected if the probability of fiber connections exceeded a statistical criterion. The topological parameters of the established cortical network (binarized) resemble that of a "small-world" architecture characterized by an exponentially truncated power-law distribution. These characteristics imply high resilience to localized damage. Furthermore, this cortical network was characterized by major hub regions in association cortices that were connected by bridge connections following long-range white matter pathways. Our results are compatible with previous structural and functional brain networks studies and provide insight into the organizational principles of human brain anatomical networks that underlie functional states.
Authors:
Gaolang Gong; Yong He; Luis Concha; Catherine Lebel; Donald W Gross; Alan C Evans; Christian Beaulieu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-06-20
Journal Detail:
Title:  Cerebral cortex (New York, N.Y. : 1991)     Volume:  19     ISSN:  1460-2199     ISO Abbreviation:  Cereb. Cortex     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-06     Completed Date:  2009-12-17     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  9110718     Medline TA:  Cereb Cortex     Country:  United States    
Other Details:
Languages:  eng     Pagination:  524-36     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, 1098 Research Transition Facility, University of Alberta, Edmonton, Alberta, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Brain Mapping / methods*
Cerebral Cortex / anatomy & histology*,  physiology*
Diffusion Magnetic Resonance Imaging / methods*
Female
Humans
Male
Nerve Net / anatomy & histology*,  physiology*
Neural Pathways / anatomy & histology,  physiology
Young Adult
Grant Support
ID/Acronym/Agency:
P41 RR15241/RR/NCRR NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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