| Mapping QTL for metabolic and cytological fatness traits of connected F2 crosses in pigs. | |
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MedLine Citation:
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PMID: 21926318 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In the present study three connected F(2) crosses were used to map QTL for classical fat traits as well as fat related metabolic and cytological traits in pigs. The founder breeds were Chinese Meishan, European Wild Boar and Pietrain with to some extent same founder animals in different crosses. The different selection history of the breeds for fatness traits as well as the connectedness of the crosses led to a high statistical power. The total number of F(2) animals varied between 694 and 966, depending on the trait. The animals were genotyped for around 250 genetic markers, mostly microsatellites. The statistical model was a multi allele multi QTL model that accounted for imprinting. The model was previously introduced from plant breeding experiments. The traits investigated were back fat depth and fat area as well as relative number of fat cells with different sizes and two metabolic traits, i.e. soluble protein content as an indicator for the level of metabolic turnover and NADP-malat dehydrogenase as an indicator for enzyme activity. The results revealed in total 37 significant QTL on chromosomes 1, 2, 4, 5, 6, 7, 8, 9, 14, 17 and 18, with often an overlap of confidence intervals of several traits. These confidence intervals were in some cases remarkably small, which is due to the high statistical power of the design. In total 18 QTL showed significant imprinting effects. The small and overlapping confidence intervals for the classical fatness traits as well as for the cytological and metabolic traits enabled positional and functional candidate gene identification for several mapped QTL. |
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Authors:
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C Rückert; P Stratz; S Preuss; J Bennewitz |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-16 |
Journal Detail:
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Title: Journal of animal science Volume: - ISSN: 1525-3163 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8003002 Medline TA: J Anim Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institute of Animal Husbandry and Breeding, University of Hohenheim, D-70599 Stuttgart, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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