| Mapping of lymphatic drainage from the prostate using filtered 99mTc-sulfur nanocolloid and SPECT/CT. | |
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MedLine Citation:
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PMID: 21680690 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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METHODS: Ten patients were enrolled for this study, and all received radiotracer prepared using a 100-nm membrane filter at a commercial radiopharmacy. Whole-body scans and SPECT/CT studies were performed within 1.5-3 h after the radiotracer had been administered directly into 6 locations of the prostate gland under transrectal ultrasound guidance. The radiation dose was estimated from the first 3 patients. Lymphatic drainage mapping was performed, and lymph nodes were identified. RESULTS: The estimated radiation dose ranged from 3.9 to 5.2 mSv/MBq. The locations of lymph nodes draining the prostate gland were similar to those found using the proprietary product. CONCLUSION: When the proprietary radiolabeled nanocolloid indicated for lymphoscintigraphy is not available, prostate lymph node mapping and identification are still feasible using filtered (99m)Tc-sulfur nanocolloid. |
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Authors:
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Youngho Seo; Carina Mari Aparici; Chien Peter Chen; Charles Hsu; Norbert Kased; Carole Schreck; Nick Costouros; Randall Hawkins; Katsuto Shinohara; Mack Roach Iii |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural Date: 2011-06-16 |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 52 ISSN: 1535-5667 ISO Abbreviation: J. Nucl. Med. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-04 Completed Date: 2011-09-05 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 1068-72 Citation Subset: IM |
Affiliation:
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Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94107-1739, USA. youngho.seo@ucsf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Feasibility Studies Filtration* Humans Lymph Nodes / radiography, radionuclide imaging Lymphatic Metastasis Male Middle Aged Nanostructures / diagnostic use* Prostatic Neoplasms / pathology*, radiography, radionuclide imaging Radiation Dosage Technetium Tc 99m Sulfur Colloid / chemistry*, diagnostic use* Tomography, Emission-Computed, Single-Photon* Tomography, X-Ray Computed* |
| Grant Support | |
ID/Acronym/Agency:
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K25 CA114254/CA/NCI NIH HHS; K25 CA114254-04/CA/NCI NIH HHS; K25 CA114254-04S1/CA/NCI NIH HHS; K25 CA114254-05/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Technetium Tc 99m Sulfur Colloid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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