Document Detail


Mapping cardiac surface mechanics with structured light imaging.
MedLine Citation:
PMID:  22796539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiovascular disease often manifests as a combination of pathological electrical and structural heart remodeling. The relationship between mechanics and electrophysiology is crucial to our understanding of mechanisms of cardiac arrhythmias and the treatment of cardiac disease. While several technologies exist for describing whole heart electrophysiology, studies of cardiac mechanics are often limited to rhythmic patterns or small sections of tissue. Here, we present a comprehensive system based on ultrafast three-dimensional (3-D) structured light imaging to map surface dynamics of whole heart cardiac motion. Additionally, we introduce a novel nonrigid motion-tracking algorithm based on an isometry-maximizing optimization framework that forms correspondences between consecutive 3-D frames without the use of any fiducial markers. By combining our 3-D imaging system with nonrigid surface registration, we are able to measure cardiac surface mechanics at unprecedented spatial and temporal resolution. In conclusion, we demonstrate accurate cardiac deformation at over 200,000 surface points of a rabbit heart recorded at 200 frames/s and validate our results on highly contrasting heart motions during normal sinus rhythm, ventricular pacing, and ventricular fibrillation.
Authors:
Jacob I Laughner; Song Zhang; Hao Li; Connie C Shao; Igor R Efimov
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Video-Audio Media     Date:  2012-07-13
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  303     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-17     Completed Date:  2012-11-23     Revised Date:  2013-09-17    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H712-20     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, Washington University in Saint Louis, Missouri, USA.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Animals
Biomechanics
Cardiac Pacing, Artificial
Diagnostic Imaging / methods*
Electrocardiography
Excitation Contraction Coupling*
Heart Rate
Heart Ventricles / physiopathology*
Imaging, Three-Dimensional
Light*
Myocardial Contraction*
Perfusion
Pericardium / physiopathology*
Rabbits
Reproducibility of Results
Signal Processing, Computer-Assisted
Time Factors
Ventricular Fibrillation / diagnosis*,  physiopathology
Ventricular Function, Left*
Grant Support
ID/Acronym/Agency:
HL-067322/HL/NHLBI NIH HHS; HL-085369/HL/NHLBI NIH HHS; HL-108617/HL/NHLBI NIH HHS
Comments/Corrections

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