Document Detail

Mapping the altered patterns of cerebellar resting-state function in longitudinal amnestic mild cognitive impairment patients.
MedLine Citation:
PMID:  20930266     Owner:  NLM     Status:  MEDLINE    
The cerebellum is known to be a relatively well preserved structure, but subtle alterations may occur early in the evolution of Alzheimer's disease (AD). Amnestic mild cognitive impairment (aMCI) patients appear to be particularly vulnerable to AD. However, little is currently known whether altered patterns of cerebellar function occur in aMCI patients. 26 aMCI patients and 18 well-matched healthy controls underwent a baseline resting-state functional magnetic resonance imaging (fMRI) scan. After a mean follow-up period of 20 months, the subjects who successfully completed baseline fMRI scans underwent a further follow-up scan, while spontaneous activation and functional connectivity of the cerebellum were explored by using resting-state fMRI. Compared to controls, increased amplitude of low frequency fluctuation of the posterior cerebellar lobe may contribute to the underlying mechanisms affected, while greater decreased functional connections to the posterior cerebellar lobe were identified in the longitudinal study of aMCI patients. This suggests that abnormal functional connectivity of the cerebellum may offer a more sensitive and possibly preferred index of functional disturbance than regional activity measures in aMCI patients. The cerebellum may be partly related to the underlying mechanisms of aMCI, and it could help guide subsequent investigations designed to specify the precise functional role of cerebellum in aMCI patients.
Feng Bai; Wei Liao; David R Watson; Yongmei Shi; Yonggui Yuan; Alexander D Cohen; Chunming Xie; Yi Wang; Chunxian Yue; Yuhuan Teng; Di Wu; Jianping Jia; Zhijun Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  23     ISSN:  1875-8908     ISO Abbreviation:  J. Alzheimers Dis.     Publication Date:  2011  
Date Detail:
Created Date:  2011-01-13     Completed Date:  2011-05-05     Revised Date:  2011-08-19    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  87-99     Citation Subset:  IM    
School of Clinical Medicine, Southeast University, Nanjing, China.
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MeSH Terms
Amnesia / complications,  pathology*
Brain Mapping*
Cerebellum / blood supply,  physiopathology*
Cognition Disorders / complications,  pathology*
Image Processing, Computer-Assisted / methods
Longitudinal Studies
Magnetic Resonance Imaging / methods
Middle Aged
Neuropsychological Tests
Oxygen / blood
Psychiatric Status Rating Scales
Reproducibility of Results
Reg. No./Substance:

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