Document Detail

Many young men with prostate-specific antigen (PSA) screen-detected prostate cancers may be candidates for active surveillance.
MedLine Citation:
PMID:  23350937     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To identify a population of young men (aged <55 years at diagnosis) with very-low-risk prostate cancer (stage cT1c, with prostate-specific antigen [PSA] density of <0.15 ng/mL/g, Gleason score ≤6, and ≤2 positive biopsy cores with <50% tumour involvement) that may be candidates for active surveillance (AS).
PATIENTS AND METHODS: We queried a Department of Defense tumour registry and hard-copy records for servicemen diagnosed with prostate cancer from 1987 to 2010. Statistical analyses were undertaken using Fisher's exact and chi-square testing.
RESULTS: From 1987-1991 and 2007-2010, PSA screen-detected tumours diagnosed in men aged ≤55 years rose >30-fold. Data for a subset of men (174) with PSA screen-detected cancer were evaluable for disease risk assessment. Of the 174 men with screen-detected disease, 81 (47%) had very-low-risk disease. Of that group, 96% (78/81) selected treatment and, of 57 men undergoing radical prostatectomy (RP), the tumours of 49 (86%) carried favourable pathology (organ confined, <10% gland involvement, Gleason ≤6).
CONCLUSIONS: Nearly half of young men with PSA screen-detected prostate cancer are AS candidates but the overwhelming majority seek treatment. Considering that many tumours show favourable pathology at RP, there is a possibility that these patients may benefit from AS management.
Jeri Kim; James Ebertowski; Matthew Janiga; Jorge Arzola; Gayle Gillespie; Michael Fountain; Douglas Soderdahl; Edith Canby-Hagino; Sally Elsamanoudi; Jennifer Gurski; John W Davis; Patricia A Parker; Douglas D Boyd
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Publication Detail:
Type:  Journal Article; Multicenter Study; Retracted Publication     Date:  2013-01-25
Journal Detail:
Title:  BJU international     Volume:  111     ISSN:  1464-410X     ISO Abbreviation:  BJU Int.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-25     Completed Date:  2013-07-09     Revised Date:  2014-07-11    
Medline Journal Info:
Nlm Unique ID:  100886721     Medline TA:  BJU Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  934-40     Citation Subset:  IM    
Copyright Information:
© 2013 BJU International.
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MeSH Terms
Age Distribution
Early Detection of Cancer / methods*
Middle Aged
Military Personnel
Neoplasm Grading
Patient Selection
Population Surveillance*
Predictive Value of Tests
Prostate / pathology*
Prostate-Specific Antigen / blood*
Prostatic Neoplasms / epidemiology,  immunology*
Risk Assessment
Tumor Markers, Biological / blood*
United States / epidemiology
Grant Support
Reg. No./Substance:
0/Tumor Markers, Biological; EC Antigen
Retraction In:
BJU Int. 2014 Mar;113(3):509   [PMID:  25003161 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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