| Many forks in the path: cycling with FoxO. | |
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MedLine Citation:
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PMID: 18391972 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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FoxO transcription factors are an evolutionary conserved subfamily of the forkhead transcription factors, characterized by the forkhead DNA-binding domain. FoxO factors regulate a number of cellular processes involved in cell-fate decisions in a cell-type- and environment-specific manner, including metabolism, differentiation, apoptosis and proliferation. A key mechanism by which FoxO determines cell fate is through regulation of the cell cycle machinery, and as such the cellular consequence of FoxO deregulation is often manifested through perturbation of the cell cycle. Consequently, the deregulation of FoxO factors is implicated in the development of numerous proliferative diseases, in particular cancer. |
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Authors:
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K K Ho; S S Myatt; E W-F Lam |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Oncogene Volume: 27 ISSN: 1476-5594 ISO Abbreviation: Oncogene Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-08 Completed Date: 2008-04-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8711562 Medline TA: Oncogene Country: England |
Other Details:
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Languages: eng Pagination: 2300-11 Citation Subset: IM |
Affiliation:
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Department of Oncology, Cancer Research UK Labs, Imperial College London, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Aging Cell Cycle Cell Lineage Forkhead Transcription Factors / metabolism* Humans |
| Chemical | |
Reg. No./Substance:
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0/Forkhead Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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