| The many facets of PPARgamma: novel insights for the skeleton. | |
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MedLine Citation:
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PMID: 20407009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a nuclear receptor that functions as a master transcriptional regulator of adipocyte conversion. During PPARgamma transactivation, multiple signaling pathways interact with one another, leading to the differentiation of both white and brown adipose tissue. Ligand activation of the PPARgamma-RXR heterodimer complex also enhances insulin sensitivity, and this property has been heavily exploited to develop effective pharmacotherapies for the treatment of type 2 diabetes mellitus. PPARgamma is also expressed in stem cells and plays a critical role in mesenchymal stromal cell differentiation and lineage determination events. The many facets of PPARgamma activity within the bone marrow niche where adipocytes, osteoblasts, and hematopoietic cells reside make this molecule an attractive target for pharmacological investigation. Additional findings that osteoblasts can alter energy metabolism by influencing adiposity and insulin sensitivity, and observations of decreased bone turnover in diabetic subjects, underscore the contribution of the skeleton to systemic energy requirements. Studies into the role of PPARgamma in skeletal acquisition and maintenance may lead to a better understanding of the molecular mechanisms governing stromal cell differentiation in the mesenchyme compartment and whether PPARgamma activity can be manipulated to benefit skeletal remodeling events and energy metabolism. |
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Authors:
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Masanobu Kawai; Kyle M Sousa; Ormond A MacDougald; Clifford J Rosen |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-04-20 |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: 299 ISSN: 1522-1555 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-07-14 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E3-9 Citation Subset: IM |
Affiliation:
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Maine Medical Center Research Institute, Scarborough, ME 04074, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipogenesis
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physiology Adipose Tissue, Brown / physiology* Adipose Tissue, White / physiology* Animals Bone Remodeling / physiology Bone and Bones / cytology, physiology* Humans Mesenchymal Stem Cells / physiology PPAR gamma / physiology* Skeleton |
| Grant Support | |
ID/Acronym/Agency:
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AR-45433/AR/NIAMS NIH HHS; AR-54604/AR/NIAMS NIH HHS; DE-007057/DE/NIDCR NIH HHS; DK-070071/DK/NIDDK NIH HHS; DK-51563/DK/NIDDK NIH HHS; DK-62876/DK/NIDDK NIH HHS; R24 DK-084970/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/PPAR gamma |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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