Document Detail

Manual hyperinflation causes norepinephrine release.
MedLine Citation:
PMID:  16863898     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To measure hemodynamics and plasma catecholamines during manual hyperinflation (MHI) in ventilated patients. METHODS: MHI was performed with a Mapleson "C" circuit, 2l-reservoir bag; peak inspiratory pressure was standardized to 35 mL water; and positive expiratory-end pressure of 5 mL water was administered to seven mechanically ventilated patients with septic (6) and cardiogenic (1) shock (67.2 +/- 5.2 years, Acute Physiology Assessment and Chronic Health Evaluation II score 22.1 +/- 3.1). Diastolic (DAP) and mean arterial pressure (MAP), continuous cardiac index, pulmonary artery occlusion pressure, dynamic compliance, plasma norepinephrine and epinephrine, and arterial blood gases were recorded, and systemic vascular resistance index (SVRI) and oxygenation ratio were calculated. RESULTS: There were no significant changes in pulmonary artery occlusion pressure, mean arterial pressure, or PaO2/FiO2. There were significant increases in SVRI (P < .001), DAP (P < .001), dynamic compliance (P < .01), and plasma norepinephrine (P < .001) and a decrease in cardiac index (P < .05) after MHI. CONCLUSIONS: The increases in DAP, SVRI, and plasma norepinephrine suggest a sympathetic vasoconstrictive response during the application of MHI.
Jennifer Paratz; Jeffrey Lipman
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Heart & lung : the journal of critical care     Volume:  35     ISSN:  0147-9563     ISO Abbreviation:  Heart Lung     Publication Date:    2006 Jul-Aug
Date Detail:
Created Date:  2006-07-25     Completed Date:  2006-08-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0330057     Medline TA:  Heart Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  262-8     Citation Subset:  AIM; IM    
Department of Anaesthesiology and Critical Care, University of Queensland, Royal Brisbane Hospital, Brisbane, Australia.
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MeSH Terms
Biological Markers / blood
Blood Pressure / physiology
Chromatography, High Pressure Liquid
Epinephrine / blood
Follow-Up Studies
Norepinephrine / blood*
Prospective Studies
Respiration, Artificial / methods*
Respiratory Insufficiency / blood*,  physiopathology,  therapy*
Severity of Illness Index
Stroke Volume / physiology
Reg. No./Substance:
0/Biological Markers; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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