Document Detail


Manual dexterity correlating with right lobule VI volume in right-handed 14-year-olds.
MedLine Citation:
PMID:  21925277     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Dexterity is a fundamental skill in our everyday life. Particularly, the fine-tuning of reaching for objects is of high relevance and crucially coordinated by the cerebellum. Although neuronal cerebellar structures mediate dexterity, classical whole brain voxel-based morphometry (VBM) has not identified structural correlates of dexterity in the cerebellum.
METHODS: Clusters of gray matter (GM) volume associated with the Purdue Pegboard Dexterity Test, a test of fine motor skills and complex upper limb movements, were identified in a cerebellum-optimized VBM analysis using the Spatially Unbiased Infratentorial (SUIT) toolbox in 65 healthy, right-handed 14-year-olds. For comparison, classical whole brain VBM was performed.
RESULTS: The cerebellum-optimized VBM indicated a significant positive correlation between manual dexterity and GM volume in the right cerebellum Lobule VI, corrected for multiple comparisons and non-stationary smoothness. The classical whole brain VBM revealed positive associations (uncorrected) between dexterity performance and GM volume in the left SMA (BA 6), right fusiform gyrus (BA 20) and left cuneus (BA 18), but not cerebellar structures.
CONCLUSIONS: The results indicate that cerebellar GM volumes in the right Lobule VI predict manual dexterity in healthy untrained humans when cerebellum-optimized VBM is employed. Although conventional VBM identified brain motor network areas it failed to detect cerebellar structures. Thus, previous studies might have underestimated the importance of cerebellum in manual dexterity.
Authors:
Simone Kühn; Alexander Romanowski; Christina Schilling; Tobias Banaschewski; Alexis Barbot; Gareth J Barker; Rüdiger Brühl; Christian Büchel; Patricia J Conrod; Katharina Czech; Jeff W Dalley; Herta Flor; Hugh Garavan; Ines Häke; Bernd Ittermann; Nikolay Ivanov; Karl Mann; Mark Lathrop; Eva Loth; Katharina Lüdemann; Catherine Mallik; Jean-Luc Martinot; Carla Palafox; Jean-Baptiste Poline; Jan Reuter; Marcella Rietschel; Trevor W Robbins; Michael N Smolka; Frauke Nees; Bernadeta Walaszek; Gunter Schumann; Andreas Heinz; Jürgen Gallinat;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-09-08
Journal Detail:
Title:  NeuroImage     Volume:  59     ISSN:  1095-9572     ISO Abbreviation:  Neuroimage     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-05     Completed Date:  2012-04-17     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1615-21     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Cerebellum / physiology*
Female
Functional Laterality / physiology*
Humans
Imaging, Three-Dimensional / methods*
Magnetic Resonance Imaging / methods*
Male
Organ Size
Psychomotor Performance / physiology*
Statistics as Topic
Grant Support
ID/Acronym/Agency:
G0901858//Medical Research Council; //Department of Health; //Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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