| Manual approach during hand gesture imitation. | |
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MedLine Citation:
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PMID: 12223035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Patients' tendency to draw near or into the target when copying figures, a phenomenon termed closing-in, has been previously described. That the closing-in could occur when copying hand gestures has also been noted. OBJECTIVES: To study a patient with corticobasal degeneration to quantify his manual approach behavior and to test a possible working memory hypothesis. METHODS: The subject of this study is a patient with severe ideomotor apraxia from probable corticobasal degeneration. Fluorine 18-labeled deoxyglucose-positron emission tomographic findings revealed a hypometabolism involving the bilateral parietotemporal and the right frontal lobes. When asked to copy an examiner's (J.C.K.) hand gesture, the patient approached, touched, or grasped the examiner's hand, a behavior mostly consistent with the closing-in behavior previously proposed. To investigate the frequency and severity of closing-in, the patient was asked to copy 20 meaningless hand gestures (10 simple and 10 complex). Copying the 20 hand gestures was performed with either the left or the right hand while the patient was seated opposite the examiner (across condition) or on the same side of the examiner (lateral condition). RESULTS: Of the 80 trials, closing-in occurred in 43 (53.8%) (35 with approaching, 6 with touching, and 2 with grasping). The closing-in was more frequent and more severe when gesturing with the left than the right hand, but it did not differ between the lateral and across conditions and between simple and complex gestures. CONCLUSIONS: Corticobasal degeneration might be associated with aberrant manual approach behavior. Although our results do not support the working memory hypothesis, frontal dysfunction might have led to a loss of voluntary control of ontologically primitive propensity to move the forelimb in the direction to which one attends. |
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Authors:
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Jay C Kwon; Sue J Kang; Byung H Lee; Juhee Chin; Kenneth M Heilman; Duk L Na |
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Publication Detail:
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Type: Case Reports; Clinical Trial; Journal Article |
Journal Detail:
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Title: Archives of neurology Volume: 59 ISSN: 0003-9942 ISO Abbreviation: Arch. Neurol. Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-09-11 Completed Date: 2002-10-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 1468-75 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong Kangnam-ku, Seoul 135-710, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Apraxias / physiopathology Behavior / physiology* Fluorodeoxyglucose F18 / diagnostic use Frontal Lobe / physiopathology, radionuclide imaging Gestures* Hand / physiology Hand Strength Humans Male Memory, Short-Term / physiology Movement / physiology* Neurodegenerative Diseases / physiopathology*, psychology, radionuclide imaging Radiopharmaceuticals / diagnostic use Tomography, Emission-Computed |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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