Document Detail

Mantle cell lymphoma.
MedLine Citation:
PMID:  7950478     Owner:  NLM     Status:  MEDLINE    
The term mantle cell lymphoma (MCL) has been introduced recently, to describe lymphomas related to the primary B follicle and the mantle of the secondary lymphoid follicle. MCL forms a subset of diffuse small cleaved cell lymphomas according to the Working Formulation and correspond closely to the centrocytic lymphomas described in the Kiel classification. They form a distinct clinico-pathological entity and are associated with a specific cytogenetic abnormality; the t(11;14)(q13;q32), which can be detected at a molecular level by rearrangement of the bcl-1 oncogene. As diagnostic criteria for MCL have now been precisely outlined and the clinical presentation described, it should be possible in the future to develop rational treatment protocols for this group of patients, who have a notoriously poor prognosis.
E Vandenberghe
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Blood reviews     Volume:  8     ISSN:  0268-960X     ISO Abbreviation:  Blood Rev.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-12-06     Completed Date:  1994-12-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8708558     Medline TA:  Blood Rev     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  79-87     Citation Subset:  IM    
University College London Medical School, Dept Haematology, UK.
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MeSH Terms
Cell Differentiation / physiology
Gene Rearrangement
Lymphoma, B-Cell / genetics,  pathology*,  therapy
Translocation, Genetic

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