Document Detail

Manometric study of the activity of alizapride on the motor function of the human sphincter of Oddi.
MedLine Citation:
PMID:  3235478     Owner:  NLM     Status:  MEDLINE    
Alizapride is a potent antiemetic, acting as a dopamine receptor antagonist on the chemoreceptor trigger zone with few gastrokinetic properties. Little is known of its activity on the human sphincter of Oddi (SO). The aim of this study was to assess the effect of alizapride on SO motor function and to evaluate a possible use of alizapride in premedication for endoscopy of the upper digestive tract. We selected ten patients who underwent retrograde cholangiopancreaticography, but had no evidence of biliary or pancreatic disease. Endoscopic manometry was applied before and for 10 min after administration of alizapride 100 mg i.v. No significant modification of basal pressure or phasic activity was observed. Alizapride can be proposed as an antiemetic in patients with biliary disorders.
P L Warzee; C C Dive
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical pharmacy and therapeutics     Volume:  13     ISSN:  0269-4727     ISO Abbreviation:  J Clin Pharm Ther     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1989-04-21     Completed Date:  1989-04-21     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  8704308     Medline TA:  J Clin Pharm Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  281-4     Citation Subset:  IM    
Department of Gastroenterology, University Hospital of St Luc, Brussels, Belgium.
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MeSH Terms
Antiemetics / adverse effects,  pharmacology*
Injections, Intravenous
Middle Aged
Muscle Contraction / drug effects
Muscles / drug effects*
Pyrrolidines / adverse effects,  pharmacology*
Reg. No./Substance:
0/Antiemetics; 0/Pyrrolidines; 59338-93-1/alizapride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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