| Manometric study of the activity of alizapride on the motor function of the human sphincter of Oddi. | |
| | |
MedLine Citation:
|
PMID: 3235478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Alizapride is a potent antiemetic, acting as a dopamine receptor antagonist on the chemoreceptor trigger zone with few gastrokinetic properties. Little is known of its activity on the human sphincter of Oddi (SO). The aim of this study was to assess the effect of alizapride on SO motor function and to evaluate a possible use of alizapride in premedication for endoscopy of the upper digestive tract. We selected ten patients who underwent retrograde cholangiopancreaticography, but had no evidence of biliary or pancreatic disease. Endoscopic manometry was applied before and for 10 min after administration of alizapride 100 mg i.v. No significant modification of basal pressure or phasic activity was observed. Alizapride can be proposed as an antiemetic in patients with biliary disorders. |
| | |
Authors:
|
P L Warzee; C C Dive |
Related Documents
:
|
10070048 - Effects of duodenal distension on antropyloroduodenal pressures and perception are modi... 7557138 - Effect of atropine on the frequency of reflux and transient lower esophageal sphincter ... 2596608 - Opening mechanisms of the human upper esophageal sphincter. 6145368 - Barrier pressure and muscle relaxants. comparison of the effects of pancuronium and vec... 7202828 - Irreversible thermic shock in rats: methods and results of a standardized shock model. 7226598 - Prevalence of primary t-wave changes in young men and their relationship to psychologic... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of clinical pharmacy and therapeutics Volume: 13 ISSN: 0269-4727 ISO Abbreviation: J Clin Pharm Ther Publication Date: 1988 Aug |
Date Detail:
|
Created Date: 1989-04-21 Completed Date: 1989-04-21 Revised Date: 2008-05-28 |
Medline Journal Info:
|
Nlm Unique ID: 8704308 Medline TA: J Clin Pharm Ther Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 281-4 Citation Subset: IM |
Affiliation:
|
Department of Gastroenterology, University Hospital of St Luc, Brussels, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Antiemetics / adverse effects, pharmacology* Female Humans Injections, Intravenous Male Manometry Middle Aged Muscle Contraction / drug effects Muscles / drug effects* Pyrrolidines / adverse effects, pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Antiemetics; 0/Pyrrolidines; 59338-93-1/alizapride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: TDM of theophylline--compliance evaluation.
Next Document: The use of diuretic medicines by elderly people in residential homes.