| Manometric features of eosinophilic esophagitis in esophageal pressure topography. | |
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MedLine Citation:
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PMID: 21091849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although most of the patients with eosinophilic esophagitis (EoE) have mucosal and structural changes that could potentially explain their symptoms, it is unclear whether EoE is associated with abnormal esophageal motor function. The aims of this study were to evaluate the esophageal pressure topography (EPT) findings in EoE and to compare them with controls and patients with gastro-esophageal disease (GERD). METHODS: Esophageal pressure topography studies in 48 EoE patients, 48 GERD patients, and 50 controls were compared. The esophageal contractile pattern was described for ten 5-mL swallows for each subject and each swallow was secondarily characterized based on the bolus pressurization pattern: absent, pan-esophageal pressurization, or compartmentalized distal pressurization. KEY RESULTS: Thirty-seven percent of EoE patients were classified as having abnormal esophageal motility. The most frequent diagnoses were of weak peristalsis and frequent failed peristalsis. Although motility disorders were more frequent in EoE patients than in controls, the prevalence and type were similar to those observed in GERD patients (P=0.61, chi-square test). Pan-esophageal pressurization was present in 17% of EoE and 2% of GERD patients while compartmentalized pressurization was present in 19% of EoE and 10% of GERD patients. These patterns were not seen in control subjects. CONCLUSIONS & INFERENCES: The prevalence of abnormal esophageal motility in EoE was approximately 37% and was similar in frequency and type to motor patterns observed in GERD. Eosinophilic esophagitis patients were more likely to have abnormal bolus pressurization patterns during swallowing and we hypothesize that this may be a manifestation of reduced esophageal compliance. |
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Authors:
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S Roman; I Hirano; M A Kwiatek; N Gonsalves; J Chen; P J Kahrilas; J E Pandolfino |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-11-23 |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 23 ISSN: 1365-2982 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-09 Completed Date: 2011-05-31 Revised Date: 2012-03-07 |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
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Languages: eng Pagination: 208-14, e111 Citation Subset: IM |
Copyright Information:
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© 2010 Blackwell Publishing Ltd. |
Affiliation:
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Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611-2951, USA. roman.sabine@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Deglutition / physiology Eosinophilic Esophagitis / pathology*, physiopathology* Esophagus / anatomy & histology, pathology*, physiology* Female Gastroesophageal Reflux / pathology, physiopathology Humans Male Manometry / methods* Middle Aged Muscle Contraction / physiology Pressure Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK056033/DK/NIDDK NIH HHS; R01 DK079902/DK/NIDDK NIH HHS; R01 DK079902-02/DK/NIDDK NIH HHS; R01 DK079902-03/DK/NIDDK NIH HHS |
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