| Mannose-mediated targeted immunoadjuvant action of liposomes. | |
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MedLine Citation:
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PMID: 3169846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of the ligand mannosylated albumin, covalently coupled to the surface of tetanus toxoid-containing dehydration-rehydration vesicles (DRV), on their adjuvanticity was investigated. Toxoid-containing DRV coated with mannosylated albumin bound in vitro to mouse (BALB/c) peritoneal macrophages selectively and to a greater extent than non-mannosylated DRV. ELISA assays of anti-toxoid IgG1 and IgG2b in the sera of BALB/c mice immunized with various toxoid-containing DRV preparations suggest that mannosylated liposomes are superior in immunoadjuvant action to conventional ones. Such targeted adjuvanticity appears to be influenced by the number of ligand molecules available on the surface of liposomes rather than the number of mannose residues on albumin. |
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Authors:
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N Garcon; G Gregoriadis; M Taylor; J Summerfield |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Immunology Volume: 64 ISSN: 0019-2805 ISO Abbreviation: Immunology Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1988-11-21 Completed Date: 1988-11-21 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0374672 Medline TA: Immunology Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 743-5 Citation Subset: IM |
Affiliation:
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Medical Research Council Group, Royal Free Hospital School of Medicine, London, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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pharmacology* Animals Antibodies, Bacterial / biosynthesis Liposomes / immunology*, metabolism Macrophages / metabolism Mannose / immunology* Mice Mice, Inbred BALB C Tetanus Toxoid / immunology |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Antibodies, Bacterial; 0/Liposomes; 0/Tetanus Toxoid; 31103-86-3/Mannose |
| Comments/Corrections | |
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