| Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation. | |
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MedLine Citation:
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PMID: 20399528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The first line of host defense is the innate immune system that includes coagulation factors and pattern recognition molecules, one of which is mannose-binding lectin (MBL). Previous studies have demonstrated that MBL deficiency increases susceptibility to infection. Several mechanisms are associated with increased susceptibility to infection, including reduced opsonophagocytic killing and reduced lectin complement pathway activation. In this study, we demonstrate that MBL and MBL-associated serine protease (MASP)-1/3 together mediate coagulation factor-like activities, including thrombin-like activity. MBL and/or MASP-1/3 deficient hosts demonstrate in vivo evidence that MBL and MASP-1/3 are involved with hemostasis following injury. Staphylococcus aureus infected MBL null mice developed disseminated intravascular coagulation (DIC), which was associated with elevated blood IL-6 levels (but not TNF-α and multi-organ inflammatory responses). Infected MBL null mice also develop liver injury. These findings suggest that MBL deficiency may manifest into DIC and organ failure during infectious diseases. |
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Authors:
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Kazue Takahashi; Wei-Chuan Chang; Minoru Takahashi; Vasile Pavlov; Yumi Ishida; Laura La Bonte; Lei Shi; Teizo Fujita; Gregory L Stahl; Elizabeth M Van Cott |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-03-04 |
Journal Detail:
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Title: Immunobiology Volume: 216 ISSN: 1878-3279 ISO Abbreviation: Immunobiology Publication Date: 2011 Jan-Feb |
Date Detail:
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Created Date: 2010-11-29 Completed Date: 2011-07-18 Revised Date: 2012-01-04 |
Medline Journal Info:
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Nlm Unique ID: 8002742 Medline TA: Immunobiology Country: Netherlands |
Other Details:
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Languages: eng Pagination: 96-102 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier GmbH. All rights reserved. |
Affiliation:
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Developmental Immunology Program, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. ktakahashi1@partners.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adoptive Transfer Animals Blood Coagulation / genetics Complement Pathway, Mannose-Binding Lectin / genetics Disease Susceptibility Disseminated Intravascular Coagulation / epidemiology, genetics, immunology*, physiopathology Interleukin-6 / genetics, metabolism Liver / immunology, metabolism, microbiology, pathology Mannose-Binding Lectin / genetics, immunology, metabolism* Mannose-Binding Protein-Associated Serine Proteases / genetics, immunology, metabolism* Mice Mice, Inbred C57BL Mice, Knockout Risk Factors Staphylococcal Infections / epidemiology, genetics, immunology*, physiopathology Staphylococcus aureus / immunology*, pathogenicity Thrombin / immunology, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01HL52886/HL/NHLBI NIH HHS; R01HL56086/HL/NHLBI NIH HHS; R21 AI077081-01/AI/NIAID NIH HHS; R21 AI077081-02/AI/NIAID NIH HHS; R21AI077081/AI/NIAID NIH HHS; R21HL092469/HL/NHLBI NIH HHS; R56HL056086/HL/NHLBI NIH HHS; RC1HL099130/HL/NHLBI NIH HHS; U01 AI074503/AI/NIAID NIH HHS; U01 AI074503-01/AI/NIAID NIH HHS; U01 AI074503-02/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/Mannose-Binding Lectin; EC 3.4.21.-/Mannose-Binding Protein-Associated Serine Proteases; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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