Document Detail


Mannose-binding lectin in term newborns and their mothers: genotypic and phenotypic relationship.
MedLine Citation:
PMID:  18571005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Functional mannose-binding lectin (f-MBL) plays an important role in the innate neonatal immune system. We studied the origin of f-MBL in umbilical cord blood (UCB) by measuring maternal MBL (n=47), collected before elective cesarean section, and neonatal MBL (n=43) in arterial umbilical cord blood. In a subgroup, arterial and venous UCB MBL levels were measured. In addition, MBL expression was correlated with genetic mutations. The f-MBL levels in term infants were lower than in their mothers (0.70 microg/ml vs 1.11 microg/ml, p<0.01) and maternal and neonatal MBL levels were only weakly correlated (R=0.32, p<0.001), which suggests a fetal origin of f-MBL. Arterial and venous UCB median MBL levels did not differ (0.98 microg/ml vs. 1.40 microg/ml, p=0.20). No homozygous mutations were found. MBL was lower in mothers and infants with a (compound) heterozygous mutation than in those with a wild type. One new (HYPB) and two rare haplotypes (HXPA, LYPD) were reported in our population. Levels of MBL differed depending on the genotype of the mother or the infant. Because the role of MBL in host defense is still unclear, both f-MBL and haplotype should be measured to determine the clinical implications of MBL deficiency in infants.
Authors:
Anne-Mieke J Oudshoorn; Frank A M van den Dungen; Kitty P Bach; Irene Koomen; Willem P F Fetter; Arnold Catsburg; Paul H M Savelkoul; Ruurd M van Elburg
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-05-19
Journal Detail:
Title:  Human immunology     Volume:  69     ISSN:  0198-8859     ISO Abbreviation:  Hum. Immunol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-23     Completed Date:  2008-08-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8010936     Medline TA:  Hum Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  344-8     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Division of Neonatology, VU University Medical Center, Amsterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Female
Fetal Blood
Genetic Predisposition to Disease
Haplotypes
Heterozygote
Humans
Immunity, Innate / genetics*
Immunity, Maternally-Acquired
Infant, Newborn
Male
Mannose-Binding Lectin / blood,  genetics*,  immunology*
Mutation
Phenotype
Polymorphism, Genetic
Pregnancy
Chemical
Reg. No./Substance:
0/Mannose-Binding Lectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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