| Mannose-binding lectin gene polymorphisms are associated with disease activity and physical disability in untreated, anti-cyclic citrullinated peptide-positive patients with early rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 19273450 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the association between polymorphisms in the mannose-binding lectin gene (MBL2) and disease activity, physical disability, and joint erosions in patients with newly diagnosed rheumatoid arthritis (RA). METHODS: Patients with early RA (n=158) not previously treated with disease modifying antirheumatic drugs, participating in a treatment trial (CIMESTRA study) were examined at inclusion for MBL2 pooled structural genotypes (O/O, A/O, A/A), regulatory MBL2 promoter polymorphism in position -221 (XX, XY, YY), anti-cyclic citrullinated peptide 2 antibodies (anti-CCP2), disease activity by Disease Activity Score-28 (DAS28 score), physical disability by Health Assessment Questionnaire (HAQ) score, and erosive changes in hands and feet (Sharp-van der Heijde score). RESULTS: Eight patients were homozygous MBL2 defective (O/O), 101 belonged to an intermediate group, and 49 were MBL2 high producers (YA/YA). Anti-CCP was present in 93 patients (59%). High scores of disease activity, C-reactive protein-based DAS28 (p=0.02), and physical disability by HAQ (p=0.01) were associated with high MBL2 expression genotypes in a gene-dose dependent way, but only in anti-CCP-positive patients. At this early stage of the disease there was no association with erosion score from radiographs. CONCLUSION: The results point to a synovitis-enhancing effect of MBL in anti-CCP-positive RA, whereas such an effect was not demonstrated for joint erosions. |
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Authors:
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Søren Jacobsen; Peter Garred; Hans Ole Madsen; Niels H H Heegaard; Merete Lund Hetland; Kristian Stengaard-Pedersen; Peter Junker; Tine Lottenburger; Torkel Ellingsen; Lis Smedegaard Andersen; Ib Hansen; Henrik Skjødt; Jens Kristian Pedersen; Ulrik Birk Lauridsen; Anders J Svendsen; Ulrik Tarp; Jan Pødenphant; Hanne Lindegaard; Aage Vestergaard; Mikkel Østergaard; Kim Hørslev-Petersen |
Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-02-27 |
Journal Detail:
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Title: The Journal of rheumatology Volume: 36 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-03 Completed Date: 2009-06-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: Canada |
Other Details:
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Languages: eng Pagination: 731-5 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. sj@dadlnet.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arthritis, Rheumatoid / genetics*, immunology, pathology, physiopathology* Autoantibodies / blood, immunology* Disability Evaluation Double-Blind Method Female Humans Mannose-Binding Lectin / genetics* Middle Aged Peptides, Cyclic / immunology* Polymorphism, Genetic* Promoter Regions, Genetic / genetics Questionnaires Severity of Illness Index Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/MBL2 protein, human; 0/Mannose-Binding Lectin; 0/Peptides, Cyclic; 0/cyclic citrullinated peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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