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Mannose-binding lectin gene polymorphism and risk factors for cardiovascular disease in postmenopausal women.
MedLine Citation:
PMID:  24861434     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Inflammatory responses may be altered in postmenopausal women and predispose to cardiovascular disease (CVD). Genetic factors can also influence susceptibility to CVD. Mannose-binding lectin (MBL) is a component of the innate immune system and an activator of the complement cascade. We evaluated the association of genetic polymorphism of MBL (MBL2) on risk factors for CVD in postmenopausal women.
METHODS: In this cross-sectional study, 311 Brazilian women (age ≥45 years and amenorrhea ≥12 months) were included. Exclusion criteria: presence of previous or current CVD, insulin dependent diabetes, chronic kidney disease, autoimmune diseases and cancer. Clinical, anthropometric and biochemical assessments were performed to evaluate the cardiovascular risk factors. DNA was extracted from buccal cell and polymorphisms at codons 54 and 57 in the MBL2 were determined by polymerase chain reaction (PCR). For statistical analysis, the chi-square and logistic regression (odds ratio, OR) were used.
RESULTS: The presence of the polymorphic allele for codon 54 was found in 25.8% of women (A/B=22.6%, B/B=3.2%) and for codon 57 in 12.2% (A/C=10.8%, C/C=1.4%). The polymorphism at codon 54 was significantly associated with the presence of hypertension (OR 0.55, 95% CI 0.31-0.99, p=0.044) and insulin resistance assessed by HOMA-IR (OR 0.46, 95% CI 0.24-0.91, p=0.025). No significant associations were observed between the polymorphism at codon 57 with risk factors for CVD.
CONCLUSION: In postmenopausal women, the polymorphism at codon 54 of the MBL2 was associated with lower risk for hypertension and insulin resistance that are important risk factors for CVD.
Authors:
Claudio Lera Orsatti; Eliana Aguiar Petri Nahás; Jorge Nahas-Neto; Fabio Lera Orsatti; Iara Moreno Linhares; Steven Sol Witkin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-23
Journal Detail:
Title:  Molecular immunology     Volume:  61     ISSN:  1872-9142     ISO Abbreviation:  Mol. Immunol.     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905289     Medline TA:  Mol Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  23-27     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ltd.
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