| Mannose binding lectin deficiency and triglyceride-rich lipoprotein metabolism in normolipidemic subjects. | |
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MedLine Citation:
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PMID: 19380135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mannose binding lectin (MBL) is one of the three initiators of complement activation and is therefore closely linked to inflammation. MBL deficiency has been associated with the generation of atherosclerosis. Since atherosclerosis, the complement system and postprandial lipemia are linked to inflammation, we studied postprandial lipoprotein metabolism in MBL deficiency. An observational study was carried out in 107 volunteers (21% MBL deficient). Classical cardiovascular risk factors were not different between subjects with and without MBL deficiency. Oral fat loading tests in 8 MBL deficient and 14 MBL sufficient subjects showed similar postprandial triglyceride, free fatty acid, hydroxybutyric acid and complement component 3 concentrations. MBL deficient subjects had 2.4 times lower postprandial Sf>400 (chylomicron)-apoB48 concentrations, but in contrast a 2-3.5 times increased Sf 60-400 (VLDL1-TG) and Sf 60-400-apoB100 response. MBL activity was inversely related to the postprandial Sf 60-400-TG increase. Despite lower postprandial Sf>400-apoB48 concentrations, MBL deficient subjects show an accumulation of Sf 60-400 lipoproteins. |
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Authors:
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A Alipour; A J H H M van Oostrom; J P H Van Wijk; C Verseyden; H W M Plokker; J W Jukema; A J Rabelink; M Castro Cabezas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-19 |
Journal Detail:
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Title: Atherosclerosis Volume: 206 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-05 Completed Date: 2009-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 444-50 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Sint Franciscus Gasthuis, Rotterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Dietary Fats / diagnostic use Female Humans Lipoproteins / metabolism* Male Mannose-Binding Lectin / deficiency* Middle Aged Postprandial Period Triglycerides / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Lipoproteins; 0/Mannose-Binding Lectin; 0/Triglycerides; 0/lipoprotein triglyceride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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