Document Detail

Mannose-binding lectin as a risk factor for acute coronary syndromes.
MedLine Citation:
PMID:  19711212     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Mannose-binding lectin (MBL) is a multifunctional protein involved in innate immunity. We tested whether MBL and elevated viral and bacterial antibodies were risk factors for acute coronary events. DESIGN: Controlled cohort study. METHODS: A total of 354 patients with unstable angina pectoris (UA) or acute myocardial infarction (AMI) were compared with 334 paired controls. RESULTS: Enterovirus titres were associated with increased risk of UA (odds ratio 10.04, P<0.001) and AMI (odds ratio 3.18, P=0.003), but titres did not correlate with either MBL concentration or genotype. Chlamydia pneumoniae heat shock protein 60 IgG concentrations were also associated with increased risk of UA (odds ratio 1.63, P=0.049). Compared to asymptomatic controls, patients had lower complement C3 serum concentrations (P<0.001), higher MBL serum concentration, and more frequently had MBL genotypes that determined high MBL levels (P<0.001). High MBL genotypes had odds ratios of 1.16 (P=0.010) for UA and 1.12 (P=0.007) for AMI. The elevation of MBL concentrations in the acute phase correlated with MBL concentrations after recovery (r=0.85, P<0.001). CONCLUSIONS: Elevated microbial titres, indicating an on-going inflammation, were associated with cardiovascular events. MBL might have a dual role both decreasing susceptibility to infections and increasing the risk of acute coronary syndromes.
Erkki Pesonen; Mikko Hallman; Seppo Sarna; Eva Andsberg; Ritva Haataja; Seppo Meri; Kenneth Persson; Mirja Puolakkainen; Hans Ohlin; Lennart Truedsson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of medicine     Volume:  41     ISSN:  1365-2060     ISO Abbreviation:  Ann. Med.     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-21     Completed Date:  2010-03-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906388     Medline TA:  Ann Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  591-8     Citation Subset:  IM    
Department of Pediatric Cardiology, University Hospital of Lund, Sweden.
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MeSH Terms
Angina, Unstable / etiology*,  genetics,  microbiology
Antibodies, Bacterial / analysis
Antibodies, Viral / analysis
Case-Control Studies
Chaperonin 60 / immunology
Chlamydophila pneumoniae / immunology
Cohort Studies
Complement C3 / metabolism
Enterovirus / immunology
Genetic Predisposition to Disease
Inflammation / etiology,  microbiology
Mannose-Binding Lectin / blood*,  genetics
Middle Aged
Myocardial Infarction / etiology*,  genetics,  microbiology
Risk Factors
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Antibodies, Viral; 0/Chaperonin 60; 0/Complement C3; 0/Mannose-Binding Lectin

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