Document Detail


Mannose-binding lectin (MBL) genotype in relation to risk of nosocomial infection in pre-term neonates in the neonatal intensive care unit.
MedLine Citation:
PMID:  18031556     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mannose-binding lectin (MBL) plays an important role in the innate immune response. Three alleles in the MBL gene, and one allele of the promoter, independently cause low serum MBL levels as compared with the wild-type. This study investigated the relationship between MBL genotype and the occurrence of nosocomial infection among neonates in a neonatal intensive care unit (NICU). Prospectively gathered information concerning nosocomial infection was available for 742 neonates from a recently performed surveillance study in an NICU. DNA was isolated from Guthriecards for a subgroup of 204 neonates who stayed in the NICU for > or =4 days. After a pre-PCR for the MBL gene in blood spots on Guthriecards, mutations were analysed by real-time PCR to detect six mutations in the MBL gene. An MBL genotype could be determined for 186 neonates. As compared to term neonates, genotypes encoding MBL-deficient haplotypes were significantly more prevalent among pre-term neonates. Forty-one of these neonates developed sepsis, with blood cultures yielding coagulase-negative staphylococci in 25 cases. Pneumonia occurred in 30 cases, with various causative organisms. No relationship was found between MBL genotype and the risk of nosocomial sepsis or pneumonia, even after correction for birth-weight, perhaps because of an insufficient correlation between genotype and the concentration of functional MBL. In addition, most bloodstream infections in the NICU were caused by coagulase-negative staphylococci, to which MBL binds poorly.
Authors:
W C van der Zwet; A Catsburg; R M van Elburg; P H M Savelkoul; C M J E Vandenbroucke-Grauls
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-21
Journal Detail:
Title:  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases     Volume:  14     ISSN:  1198-743X     ISO Abbreviation:  Clin. Microbiol. Infect.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-10     Completed Date:  2008-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9516420     Medline TA:  Clin Microbiol Infect     Country:  France    
Other Details:
Languages:  eng     Pagination:  130-5     Citation Subset:  IM    
Affiliation:
Department of Medical Microbiology and Infection Control, VU University Medical Centre, Amsterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Bacterial Infections / epidemiology,  genetics*,  microbiology
Cross Infection / epidemiology,  genetics*,  microbiology
Genotype
Humans
Incidence
Infant, Newborn
Intensive Care, Neonatal
Mannose-Binding Lectin / deficiency,  genetics*
Multivariate Analysis
Netherlands / epidemiology
Polymorphism, Single Nucleotide
Prospective Studies
Retrospective Studies
Risk Factors
Chemical
Reg. No./Substance:
0/MBL2 protein, human; 0/Mannose-Binding Lectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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