Document Detail

Mannose-binding lectin-2 genotypes and recurrent late pregnancy losses.
MedLine Citation:
PMID:  18927129     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Low levels of mannose-binding lectin (MBL) predispose to various infectious and inflammatory disorders and have been reported to be associated with recurrent early miscarriages. Recurrent late pregnancy losses (RLPL) in the second trimester is a rare but devastating syndrome where maternal rather than fetal causes are likely to play a stronger role than in early recurrent miscarriage. METHODS: We identified 75 patients with at least two late losses of pregnancies with apparently normal fetuses between gestational week 14 and 30 among patients with recurrent pregnancy losses referred to our clinic. Polymorphisms in the MBL2 gene associated with plasma MBL levels were investigated in all patients and in 104 women with two or more children and no miscarriages. The patients were divided into three groups: one with clinical signs of cervical insufficiency, one positive for the lupus anticoagulant (LAC) and an idiopathic group. RESULTS: Among all patients with RLPL, 26.7% had MBL2 genotypes associated with MBL deficiency compared with 12.5% in controls [odds ratio (OR) 2.55; 95% confidence interval (CI) 1.17-5.52; P < 0.02]. Among patients with clinical signs of cervical insufficiency or the LAC, the frequency of genotypes associated with MBL deficiency was not significantly increased. However, among 38 patients with idiopathic RLPL, 36.8% carried low-producing MBL2 genotypes, which was significantly more than in controls (OR 4.08, 95% CI 1.70-9.83, P = 0.001). CONCLUSIONS: MBL deficiency is strongly associated with idiopathic RLPL. This may point towards a role for excessive inflammatory disturbances as a cause of the syndrome.
Ole B Christiansen; Henriette S Nielsen; Marie Lund; Rudi Steffensen; Kim Varming
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Publication Detail:
Type:  Journal Article     Date:  2008-10-16
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  24     ISSN:  1460-2350     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  291-9     Citation Subset:  IM    
Fertility Clinic 4071, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
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MeSH Terms
Abortion, Habitual / genetics*
Antibodies, Antiphospholipid / blood
Gestational Age
Mannose-Binding Lectin / deficiency,  genetics*
Middle Aged
Polymorphism, Single Nucleotide
Pregnancy Outcome
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Reg. No./Substance:
0/Antibodies, Antiphospholipid; 0/MBL2 protein, human; 0/Mannose-Binding Lectin

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