Document Detail

Mannitol and glucose: effects on gastric acid secretion and endogenous gastric inhibitory polypeptide (GIP).
MedLine Citation:
PMID:  736016     Owner:  NLM     Status:  MEDLINE    
Serum gastric inhibitory polypeptide was measured in dogs prepared with Heidenhain pouches and Mann-Bollman fistulae following the intraduodenal (ID) infusion of isotonic saline, 20% glucose, or 20% mannitol. Following ID 20% glucose, serum GIP concentrations rose significantly (P less than 0.05) between 30 and 120 min and there was a significant inhibition (P less than 0.05) of acid secretion in the Heidenhain pouches between 15 and 75 min. A good correlation (r = 0.925) was found between the rise in serum GIP and the inhibition of acid secretion. Although neither ID isotonic saline nor 20% mannitol stimulated GIP release, the latter produced a significant (P less than 0.05) inhibition of acid secretion between 60 and 105 min. We conclude: (1) the inhibitory effect of acid secretion following ID glucose is mediated in part by the release of endogenous GIP; (2) glucose and mannitol probably inhibit gastric acid secretion by different mechanisms.
T M O'Dorisio; J T Spaeth; E W Martin; K R Sirinek; N R Thomford; E L Mazzaferri; S Cataland
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of digestive diseases     Volume:  23     ISSN:  0002-9211     ISO Abbreviation:  Am J Dig Dis     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404011     Medline TA:  Am J Dig Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1079-83     Citation Subset:  AIM; IM    
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MeSH Terms
Gastric Inhibitory Polypeptide / blood*,  physiology
Gastric Juice / secretion*
Gastric Mucosa / secretion*
Gastrointestinal Hormones / blood*
Glucose / pharmacology*
Glucose Solution, Hypertonic / administration & dosage,  pharmacology*
Intubation, Gastrointestinal
Mannitol / administration & dosage,  pharmacology*
Pentagastrin / pharmacology
Secretory Rate / drug effects
Sodium Chloride / pharmacology
Reg. No./Substance:
0/Gastrointestinal Hormones; 0/Glucose Solution, Hypertonic; 50-99-7/Glucose; 5534-95-2/Pentagastrin; 59392-49-3/Gastric Inhibitory Polypeptide; 69-65-8/Mannitol; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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